HCSGD entry for GTPBP4
1. General information
| Official gene symbol | GTPBP4 |
|---|---|
| Entrez ID | 23560 |
| Gene full name | GTP binding protein 4 |
| Other gene symbols | CRFG NGB NOG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | biological_process |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0008156 | Negative regulation of DNA replication | IMP | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0022408 | Negative regulation of cell-cell adhesion | IDA | biological_process |
| GO:0030336 | Negative regulation of cell migration | IDA | biological_process |
| GO:0031397 | Negative regulation of protein ubiquitination | IDA | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0033342 | Negative regulation of collagen binding | IMP | biological_process |
| GO:0042254 | Ribosome biogenesis | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050821 | Protein stabilization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0777957942 | 0.6303389119 | 0.5885780684 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0785980537 |
| GSE13712_SHEAR | Up | 0.5068096548 |
| GSE13712_STATIC | Up | 0.4087706819 |
| GSE19018 | Down | -0.7540058598 |
| GSE19899_A1 | Up | 0.2833512339 |
| GSE19899_A2 | Up | 0.5269551922 |
| PubMed_21979375_A1 | Up | 0.6160973598 |
| PubMed_21979375_A2 | Up | 0.6338120786 |
| GSE35957 | Up | 0.2141776683 |
| GSE36640 | Down | -0.1739777526 |
| GSE54402 | Up | 0.1985896181 |
| GSE9593 | Down | -0.3876844376 |
| GSE43922 | Up | 0.1637220391 |
| GSE24585 | Down | -0.3994917173 |
| GSE37065 | Down | -0.0052664854 |
| GSE28863_A1 | Down | -0.1331085134 |
| GSE28863_A2 | Up | 0.1761962385 |
| GSE28863_A3 | Down | -0.0703268399 |
| GSE28863_A4 | Up | 0.2866684935 |
| GSE48662 | Down | -0.2827888959 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019721 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028964 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92a-1-5p | MIMAT0004507 | MIRT038918 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051261 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
