HCSGD entry for FPGS
1. General information
| Official gene symbol | FPGS |
|---|---|
| Entrez ID | 2356 |
| Gene full name | folylpolyglutamate synthase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0004326 | Tetrahydrofolylpolyglutamate synthase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046655 | Folic acid metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7703559781 | 0.2546414270 | 0.9999902473 | 0.9677922766 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0467947823 |
| GSE13712_SHEAR | Down | -0.4178597312 |
| GSE13712_STATIC | Down | -0.1388285446 |
| GSE19018 | Down | -0.0112144436 |
| GSE19899_A1 | Down | -0.2928932171 |
| GSE19899_A2 | Up | 0.4723638577 |
| PubMed_21979375_A1 | Down | -0.2638804138 |
| PubMed_21979375_A2 | Up | 0.2234808193 |
| GSE35957 | Up | 0.0180485412 |
| GSE36640 | Down | -0.0094686103 |
| GSE54402 | Up | 0.0971281955 |
| GSE9593 | Up | 0.0221749986 |
| GSE43922 | Down | -0.0502080223 |
| GSE24585 | Down | -0.1162243229 |
| GSE37065 | Down | -0.1310195779 |
| GSE28863_A1 | Up | 0.0809814853 |
| GSE28863_A2 | Down | -0.1527375756 |
| GSE28863_A3 | Down | -0.3232122604 |
| GSE28863_A4 | Down | -0.0749473094 |
| GSE48662 | Up | 0.1058186247 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
| Raltitrexed | DB00293 | APRD00430 | EXPT01092 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023124 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045414 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046816 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
