HCSGD entry for ATP6V0A2

1. General information

Official gene symbolATP6V0A2
Entrez ID23545
Gene full nameATPase, H+ transporting, lysosomal V0 subunit a2
Other gene symbolsA2 ARCL ARCL2A ATP6A2 ATP6N1D J6B7 RTF STV1 TJ6 TJ6M TJ6S VPH1 WSS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000220Vacuolar proton-transporting V-type ATPase, V0 domainIEAcellular_component
GO:0001669Acrosomal vesicleIEAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006879Cellular iron ion homeostasisTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0015078Hydrogen ion transmembrane transporter activityIEAmolecular_function
GO:0015991ATP hydrolysis coupled proton transportIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0033179Proton-transporting V-type ATPase, V0 domainIEAcellular_component
GO:0033572Transferrin transportTASbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0090382Phagosome maturationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25867201850.56228977240.95225734661.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1084856235
GSE13712_SHEARUp0.0351348715
GSE13712_STATICDown-0.1748043839
GSE19018Down-0.5780927971
GSE19899_A1Up0.0297681980
GSE19899_A2Down-0.0331567701
PubMed_21979375_A1Down-0.0611477882
PubMed_21979375_A2Down-0.0365586876
GSE35957Down-0.0342619900
GSE36640Down-0.0189785529
GSE54402Up0.0377700794
GSE9593Down-0.1462469509
GSE43922Up0.0737603270
GSE24585Up0.2078282771
GSE37065Up0.0398956606
GSE28863_A1Up0.8213320717
GSE28863_A2Up1.0323748731
GSE28863_A3Down-0.5292318705
GSE28863_A4Up0.1086989648
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26611489Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells
26611489In the present study, we have identified 16 senescence-associated genes by differential proteomic analysis of the normal human diploid fibroblast cell line, TIG-1, and focused on ATP6V0A2
26611489The aim of this study is to clarify the role of ATP6V0A2, the causal gene for ARCL2, a syndrome of abnormal glycosylation and impaired Golgi trafficking, in cellular senescence program
26611489Here we showed that ATP6V0A2 is critical for cellular senescence; impaired expression of ATP6V0A2 disperses the Golgi structure and triggers senescence, suggesting that ATP6V0A2 mediates these processes
26611489FITC-lectin staining and glycoblotting revealed significantly different glycosylation structures in presenescent (young) and senescent (old) TIG-1 cells; reducing ATP6V0A2 expression in young TIG-1 cells yielded structures similar to those in old TIG-1 cells
26611489Our results suggest that senescence-associated impaired expression of ATP6V0A2 triggers changes in Golgi structure and glycosylation in old TIG-1 cells, which demonstrates a role of ATP6V0A2 in cellular senescence program
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