HCSGD entry for NNT
1. General information
| Official gene symbol | NNT |
|---|---|
| Entrez ID | 23530 |
| Gene full name | nicotinamide nucleotide transhydrogenase |
| Other gene symbols | GCCD4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003957 | NAD(P)+ transhydrogenase (B-specific) activity | TAS | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA TAS | cellular_component |
| GO:0005746 | Mitochondrial respiratory chain | TAS | cellular_component |
| GO:0006099 | Tricarboxylic acid cycle | TAS | biological_process |
| GO:0008746 | NAD(P)+ transhydrogenase activity | EXP | molecular_function |
| GO:0008750 | NAD(P)+ transhydrogenase (AB-specific) activity | IEA | molecular_function |
| GO:0015992 | Proton transport | IEA TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050661 | NADP binding | IDA IEA | molecular_function |
| GO:0051287 | NAD binding | TAS | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
| GO:0072593 | Reactive oxygen species metabolic process | IMP | biological_process |
| GO:1902600 | Hydrogen ion transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9816877854 | 0.0058393108 | 0.9999902473 | 0.1545621106 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1353039353 |
| GSE13712_SHEAR | Down | -0.2584482857 |
| GSE13712_STATIC | Down | -0.1996823696 |
| GSE19018 | Down | -0.0497177613 |
| GSE19899_A1 | Down | -0.5749204937 |
| GSE19899_A2 | Down | -1.4272151860 |
| PubMed_21979375_A1 | Down | -1.4527585032 |
| PubMed_21979375_A2 | Down | -1.0720739905 |
| GSE35957 | Down | -0.1432926223 |
| GSE36640 | Down | -0.4412364218 |
| GSE54402 | Down | -0.3442556828 |
| GSE9593 | Up | 0.1796157711 |
| GSE43922 | Down | -1.2055583064 |
| GSE24585 | Up | 0.6989204532 |
| GSE37065 | Down | -0.2550890288 |
| GSE28863_A1 | Down | -0.0726312153 |
| GSE28863_A2 | Up | 0.1790091031 |
| GSE28863_A3 | Down | -0.6371980547 |
| GSE28863_A4 | Down | -0.1149564364 |
| GSE48662 | Down | -0.5800547015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| 7-thionicotinamide-adenine-dinucleotide phosphate | DB01763 | EXPT03005 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016790 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025238 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044351 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045755 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046012 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT048367 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
