HCSGD entry for KAT6B
1. General information
| Official gene symbol | KAT6B |
|---|---|
| Entrez ID | 23522 |
| Gene full name | K(lysine) acetyltransferase 6B |
| Other gene symbols | GTPTS MORF MOZ2 MYST4 ZC2HC6B qkf querkopf |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000786 | Nucleosome | NAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA TAS | cellular_component |
| GO:0006334 | Nucleosome assembly | NAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016407 | Acetyltransferase activity | IDA | molecular_function |
| GO:0016573 | Histone acetylation | IDA | biological_process |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0070776 | MOZ/MORF histone acetyltransferase complex | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7563417651 | 0.2379889480 | 0.9999902473 | 0.9387242769 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2138492713 |
| GSE13712_SHEAR | Up | 0.0447339788 |
| GSE13712_STATIC | Down | -0.1746025326 |
| GSE19018 | Up | 0.1245433749 |
| GSE19899_A1 | Down | -0.2517260949 |
| GSE19899_A2 | Down | -0.5679541350 |
| PubMed_21979375_A1 | Down | -0.7927562484 |
| PubMed_21979375_A2 | Down | -0.2898536504 |
| GSE35957 | Up | 0.2143791819 |
| GSE36640 | Up | 0.0110206004 |
| GSE54402 | Down | -0.4261459603 |
| GSE9593 | Up | 0.2978820316 |
| GSE43922 | Down | -0.2004221390 |
| GSE24585 | Up | 0.0996848146 |
| GSE37065 | Up | 0.0868719748 |
| GSE28863_A1 | Up | 0.1552176294 |
| GSE28863_A2 | Up | 0.2016686974 |
| GSE28863_A3 | Up | 0.2702879071 |
| GSE28863_A4 | Down | -0.0339691221 |
| GSE48662 | Up | 0.2143888721 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016184 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018713 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019652 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1236-3p | MIMAT0005591 | MIRT036254 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12391155 | This family comprises MORF on chromosome 4 (MORF4) and MORF-related genes on chromosomes X and 15 (MRGX and MRG15, respectively) and is proposed to contribute to cellular senescence |
| 12391155 | Therefore, common functions of the MORFs are likely elicited through the action of a MORF/mSin3A/TLE complex |
| 10705034 | More recently we have cloned the gene on chromosome 4, MORF 4 |
| 9891081 | We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence |
| 9891081 | MORF 4 is a member of a novel family of genes with transcription factor-like motifs |
Entries Per Page
Displaying Page of
