HCSGD entry for SCRIB

1. General information

Official gene symbolSCRIB
Entrez ID23513
Gene full namescribbled planar cell polarity protein
Other gene symbolsCRIB1 SCRB1 SCRIB1 Vartul
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001843Neural tube closureIMPbiological_process
GO:0001921Positive regulation of receptor recyclingIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0008105Asymmetric protein localizationIEAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016080Synaptic vesicle targetingIEAbiological_process
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016337Cell-cell adhesionIGIbiological_process
GO:0016477Cell migrationIMPbiological_process
GO:0030027LamellipodiumIEAcellular_component
GO:0031252Cell leading edgeIDAcellular_component
GO:0032863Activation of Rac GTPase activityIMPbiological_process
GO:0034750Scrib-APC-beta-catenin complexIDAcellular_component
GO:0035089Establishment of apical/basal cell polarityIMPbiological_process
GO:0035748Myelin sheath abaxonal regionIEAcellular_component
GO:0042060Wound healingIEAbiological_process
GO:0042734Presynaptic membraneIDAcellular_component
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043615Astrocyte cell migrationIEAbiological_process
GO:0045211Postsynaptic membraneIDAcellular_component
GO:0045930Negative regulation of mitotic cell cycleIDAbiological_process
GO:0048488Synaptic vesicle endocytosisIEAbiological_process
GO:0050918Positive chemotaxisIMPbiological_process
GO:0060561Apoptotic process involved in morphogenesisIMPbiological_process
GO:0060603Mammary gland duct morphogenesisISSbiological_process
GO:0071896Protein localization to adherens junctionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38740186160.77438946850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0372168839
GSE13712_SHEARUp0.2823382956
GSE13712_STATICUp0.4067553674
GSE19018Down-0.2022774787
GSE19899_A1Up0.1211831920
GSE19899_A2Up0.3439486758
PubMed_21979375_A1Down-0.0838727162
PubMed_21979375_A2Up0.2564622928
GSE35957Down-0.3171514434
GSE36640Up0.0544295357
GSE54402Down-0.0147970023
GSE9593Down-0.4049980635
GSE43922Up0.0551352879
GSE24585Down-0.3115087986
GSE37065Down-0.0915762781
GSE28863_A1Down-0.0310514234
GSE28863_A2Down-0.0016505186
GSE28863_A3Up0.3182193502
GSE28863_A4Up0.0984042463
GSE48662Up0.1174563837

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-5pMIMAT0000690MIRT006438Luciferase reporter assayFunctional MTI21643016
hsa-miR-877-3pMIMAT0004950MIRT037202CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038838CLASHFunctional MTI (Weak)23622248
hsa-miR-766-3pMIMAT0003888MIRT039044CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041556CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044993CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.