HCSGD entry for SUZ12
1. General information
| Official gene symbol | SUZ12 |
|---|---|
| Entrez ID | 23512 |
| Gene full name | SUZ12 polycomb repressive complex 2 subunit |
| Other gene symbols | CHET9 JJAZ1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001739 | Sex chromatin | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0016574 | Histone ubiquitination | IEA | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0035098 | ESC/E(Z) complex | IDA IMP | cellular_component |
| GO:0042054 | Histone methyltransferase activity | IMP | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045596 | Negative regulation of cell differentiation | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8166675620 | 0.3466913301 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0101378119 |
| GSE13712_SHEAR | Down | -0.0144357702 |
| GSE13712_STATIC | Up | 0.0882947349 |
| GSE19018 | Down | -0.1003172374 |
| GSE19899_A1 | Up | 0.0619305674 |
| GSE19899_A2 | Down | -0.3219236238 |
| PubMed_21979375_A1 | Down | -0.1924699384 |
| PubMed_21979375_A2 | Down | -0.1807470589 |
| GSE35957 | Down | -0.3598169773 |
| GSE36640 | Down | -0.5267019786 |
| GSE54402 | Up | 0.0347498211 |
| GSE9593 | Down | -0.1427802703 |
| GSE43922 | Down | -0.0859583394 |
| GSE24585 | Up | 0.3648373306 |
| GSE37065 | Up | 0.0794246258 |
| GSE28863_A1 | Up | 0.4679580472 |
| GSE28863_A2 | Up | 0.0770607882 |
| GSE28863_A3 | Down | -0.0710623061 |
| GSE28863_A4 | Up | 0.0915928835 |
| GSE48662 | Down | -0.2307895771 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT004084 | Western blot | Non-Functional MTI | 19008416 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT007118 | Luciferase reporter assay | Functional MTI | 23451058 |
| hsa-miR-375 | MIMAT0000728 | MIRT019780 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020638 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-138-5p | MIMAT0000430 | MIRT021690 | Western blot;qRT-PCR | Functional MTI | 21770894 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030783 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047882 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051542 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24217920 | We show that SA-miRNAs-26b, 181a, 210 and 424 function in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm development (EED), enhancer of zeste homologue 2 (EZH2) and suppressor of zeste 12 homologue (Suz12), thereby activating p16 |
| 20049504 | Decreased expression of histone deacetylases (HDACs), followed by downregulation of polycomb group genes (PcGs), such as BMI1, EZH2 and SUZ12, and by upregulation of jumonji domain containing 3 (JMJD3), was observed in senescent MSCs |
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