HCSGD entry for ISCU
1. General information
| Official gene symbol | ISCU |
|---|---|
| Entrez ID | 23479 |
| Gene full name | iron-sulfur cluster scaffold homolog (E. coli) |
| Other gene symbols | 2310020H20Rik HML ISU2 NIFU NIFUN hnifU |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005506 | Iron ion binding | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0009399 | Nitrogen fixation | TAS | biological_process |
| GO:0016226 | Iron-sulfur cluster assembly | IEA TAS | biological_process |
| GO:0032947 | Protein complex scaffold | IDA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051536 | Iron-sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0140465598 | 0.9851032408 | 0.2939858506 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7840229870 |
| GSE13712_SHEAR | Up | 0.0017364580 |
| GSE13712_STATIC | Up | 0.0980620517 |
| GSE19018 | Up | 0.8628962680 |
| GSE19899_A1 | Up | 0.0662495307 |
| GSE19899_A2 | Up | 0.4997170008 |
| PubMed_21979375_A1 | Down | -0.0228757251 |
| PubMed_21979375_A2 | Up | 0.5608667992 |
| GSE35957 | Up | 0.3691409748 |
| GSE36640 | Up | 1.0201311534 |
| GSE54402 | Down | -0.1815184179 |
| GSE9593 | Up | 0.2064632018 |
| GSE43922 | Up | 0.0386208204 |
| GSE24585 | Up | 0.2658396552 |
| GSE37065 | Up | 0.0951146441 |
| GSE28863_A1 | Up | 0.1256732278 |
| GSE28863_A2 | Up | 0.2713396631 |
| GSE28863_A3 | Down | -0.2297921692 |
| GSE28863_A4 | Up | 0.1643024423 |
| GSE48662 | Up | 0.4746966132 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003163 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT003163 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19808020 |
| hsa-miR-210-3p | MIMAT0000267 | MIRT003163 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005717 | Immunoblot//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20480266 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
