HCSGD entry for BRD4

1. General information

Official gene symbolBRD4
Entrez ID23476
Gene full namebromodomain containing 4
Other gene symbolsCAP HUNK1 HUNKI MCAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000083Regulation of transcription involved in G1/S transition of mitotic cell cycleIMPbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0000794Condensed nuclear chromosomeIDA IEAcellular_component
GO:0001833Inner cell mass cell proliferationIEAbiological_process
GO:0002039P53 bindingIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005694ChromosomeIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006338Chromatin remodelingIDAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIEA IMPbiological_process
GO:0007059Chromosome segregationIEAbiological_process
GO:0010971Positive regulation of G2/M transition of mitotic cell cycleIMPbiological_process
GO:0016032Viral processIEAbiological_process
GO:0032968Positive regulation of transcription elongation from RNA polymerase II promoterIDA IMPbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0043983Histone H4-K12 acetylationIEAbiological_process
GO:0044154Histone H3-K14 acetylationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050727Regulation of inflammatory responseIDAbiological_process
GO:0070577Histone acetyl-lysine bindingIDAmolecular_function
GO:1901407Regulation of phosphorylation of RNA polymerase II C-terminal domainIDAbiological_process
GO:2000002Negative regulation of DNA damage checkpointIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44113036360.67209174040.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2234011335
GSE13712_SHEARDown-0.0896092541
GSE13712_STATICUp0.0315149961
GSE19018Down-0.0255848153
GSE19899_A1Down-0.1822555077
GSE19899_A2Up0.1679018964
PubMed_21979375_A1Up0.0705525822
PubMed_21979375_A2Up0.3885197133
GSE35957Down-0.0673665678
GSE36640Down-0.3765761336
GSE54402Up0.0586610257
GSE9593Down-0.0905130493
GSE43922Up0.0116605111
GSE24585Up0.0118885324
GSE37065Down-0.1320825491
GSE28863_A1Up0.4976274951
GSE28863_A2Up0.3380472618
GSE28863_A3Up0.3333067586
GSE28863_A4Up0.0638139210
GSE48662Up0.1275240834

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029120MicroarrayFunctional MTI (Weak)19088304
hsa-miR-2110MIMAT0010133MIRT035757CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036894CLASHFunctional MTI (Weak)23622248
hsa-miR-455-3pMIMAT0004784MIRT037828CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042219CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044471CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27261480In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer
27099234BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
27099234Here, we demonstrate that senescence also involves a global remodeling of the enhancer landscape with recruitment of the chromatin reader BRD4 to newly activated super-enhancers adjacent to key SASP genes
27099234Transcriptional profiling and functional studies indicate that BRD4 is required for the SASP and downstream paracrine signaling
27099234Consequently, BRD4 inhibition disrupts immune cell-mediated targeting and elimination of premalignant senescent cells in vitro and in vivo Our results identify a critical role for BRD4-bound super-enhancers in senescence immune surveillance and in the proper execution of a tumor-suppressive program
27099234This process links BRD4 and super-enhancers to a tumor-suppressive immune surveillance program that can be disrupted by small molecule inhibitors of the bromo and extra terminal domain family of proteins
27081696Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer
27081696Very recent results demonstrated that inhibiting the epigenetic reader BRD4 has notable efficacy in diverse cancer types
27081696We investigated the potential of BRD4 as a therapeutic target in liver malignancy
27081696BRD4 inhibition by JQ1 induced anti-tumorigenic effects including cell cycle arrest, cellular senescence, reduced wound healing capacity and soft agar colony formation in liver cancer cell lines
27081696Notably, BRD4 inhibition caused MYC-independent large-scale gene expression changes in liver cancer cells
27081696Serial gene expression analyses with SK-Hep1 liver cancer cells treated with JQ1 to delineate the key player of BRD4 inhibition identified E2F2 as the first line of downstream direct target of BRD4
27081696Further experiments including chromatin immunoprecipitation (ChIP) assay and loss of function study confirmed E2F2 as key player of BRD4 inhibition
23792448Silencing of BRD4 and MYC expression blocked cell proliferation and cell-cycle progression, while ectopic expression of MYC from a retroviral promoter rescued cells from (+)-JQ1-induced growth arrest
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