HCSGD entry for ICMT
1. General information
| Official gene symbol | ICMT |
|---|---|
| Entrez ID | 23463 |
| Gene full name | isoprenylcysteine carboxyl methyltransferase |
| Other gene symbols | HSTE14 MST098 MSTP098 PCCMT PCMT PPMT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0003880 | Protein C-terminal carboxyl O-methyltransferase activity | TAS | molecular_function |
| GO:0004671 | Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006481 | C-terminal protein methylation | TAS | biological_process |
| GO:0006612 | Protein targeting to membrane | TAS | biological_process |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0008140 | CAMP response element binding protein binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0046578 | Regulation of Ras protein signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9510763003 | 0.0993758938 | 0.9999902473 | 0.6033847520 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0268561809 |
| GSE13712_SHEAR | Up | 0.0033664129 |
| GSE13712_STATIC | Up | 0.0655165952 |
| GSE19018 | Down | -0.0760186185 |
| GSE19899_A1 | Down | -0.2669671617 |
| GSE19899_A2 | Down | -0.1260246419 |
| PubMed_21979375_A1 | Down | -0.4579939585 |
| PubMed_21979375_A2 | Down | -0.3364495347 |
| GSE35957 | Down | -0.1063685123 |
| GSE36640 | Down | -0.3441249630 |
| GSE54402 | Down | -0.3198595049 |
| GSE9593 | Up | 0.2798748553 |
| GSE43922 | Up | 0.0450058711 |
| GSE24585 | Down | -0.1017301766 |
| GSE37065 | Down | -0.1248916958 |
| GSE28863_A1 | Down | -0.2753056764 |
| GSE28863_A2 | Up | 0.3570169371 |
| GSE28863_A3 | Down | -0.3898542536 |
| GSE28863_A4 | Down | -0.2658879972 |
| GSE48662 | Up | 0.1280838966 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020175 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022702 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028069 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029560 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043333 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052699 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11985579 | These abnormal residues are specifically recognized by the repair enzyme L-isoaspartate (d-aspartate) protein O-methyltransferase (PCMT; EC 2 |
| 18647693 | The enzymatic methyl esterification of proteins, catalyzed by the enzyme S-adenosylmethionine: protein carboxyl-O-methyl transferase (PCMT), has been investigated in two age-related fractions of bovine lenses |
| 18647693 | The eukaryotic PCMT methyl esterifies peptides and proteins containing altered aspartyl residues, such as D-aspartyls and L-isoaspartyls, which can arise from the age-dependent deamidation of labile Asn residues |
| 18647693 | 4, 37 degrees C), in the presence of L-(methyl-(14)C)methionine, the in vivo precursor of the methyl donor substrate S-adenosylmethionine (AdoMet), a significant decrease in the level of protein methyl esterification was observed in the oldest cell fraction compared to the youngest one; in contrast, the in vitro activity of PCMT does not change during cell aging |
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