HCSGD entry for RYBP
1. General information
| Official gene symbol | RYBP |
|---|---|
| Entrez ID | 23429 |
| Gene full name | RING1 and YY1 binding protein |
| Other gene symbols | AAP1 DEDAF YEAF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0035518 | Histone H2A monoubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3583684510 | 0.3904862695 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1611285009 |
| GSE13712_SHEAR | Down | -0.0284253236 |
| GSE13712_STATIC | Down | -0.2587228542 |
| GSE19018 | Down | -0.2803351097 |
| GSE19899_A1 | Up | 0.1945631386 |
| GSE19899_A2 | Up | 0.1705314273 |
| PubMed_21979375_A1 | Up | 0.8809993265 |
| PubMed_21979375_A2 | Up | 0.2569816320 |
| GSE35957 | Down | -0.1218018033 |
| GSE36640 | Down | -0.2778013980 |
| GSE54402 | Up | 0.0789539901 |
| GSE9593 | Up | 0.2072185233 |
| GSE43922 | Up | 0.0415283228 |
| GSE24585 | Up | 0.3439702904 |
| GSE37065 | Up | 0.0266333662 |
| GSE28863_A1 | Up | 0.1912549192 |
| GSE28863_A2 | Down | -0.0282401028 |
| GSE28863_A3 | Down | -0.1886171270 |
| GSE28863_A4 | Down | -0.2483406157 |
| GSE48662 | Down | -0.1550637819 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT027957 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046103 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
