HCSGD entry for LARS2
1. General information
| Official gene symbol | LARS2 |
|---|---|
| Entrez ID | 23395 |
| Gene full name | leucyl-tRNA synthetase 2, mitochondrial |
| Other gene symbols | LEURS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002161 | Aminoacyl-tRNA editing activity | IEA | molecular_function |
| GO:0004823 | Leucine-tRNA ligase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006429 | Leucyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3161468561 | 0.1354429049 | 0.9999902473 | 0.7096181728 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2681973879 |
| GSE13712_SHEAR | Up | 0.1330128577 |
| GSE13712_STATIC | Up | 0.3112241537 |
| GSE19018 | Down | -0.2558530310 |
| GSE19899_A1 | Up | 0.1671230668 |
| GSE19899_A2 | Up | 0.0677869399 |
| PubMed_21979375_A1 | Up | 0.4310509603 |
| PubMed_21979375_A2 | Up | 0.5224585598 |
| GSE35957 | Down | -0.3742581665 |
| GSE36640 | Down | -0.7002429664 |
| GSE54402 | Up | 0.1240824928 |
| GSE9593 | Down | -0.2970189034 |
| GSE43922 | Up | 0.3640846381 |
| GSE24585 | Down | -0.4397140348 |
| GSE37065 | Up | 0.1163469440 |
| GSE28863_A1 | Up | 0.0666010987 |
| GSE28863_A2 | Up | 0.2329393549 |
| GSE28863_A3 | Down | -0.3340201319 |
| GSE28863_A4 | Down | -0.3889659520 |
| GSE48662 | Down | -0.6333919039 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Leucine | DB00149 | NUTR00033 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-421 | MIMAT0003339 | MIRT039362 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043125 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
