HCSGD entry for FNTA

1. General information

Official gene symbolFNTA
Entrez ID2339
Gene full namefarnesyltransferase, CAAX box, alpha
Other gene symbolsFPTA PGGT1A PTAR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004660Protein farnesyltransferase activityIDA IEAmolecular_function
GO:0004661Protein geranylgeranyltransferase activityIDAmolecular_function
GO:0004662CAAX-protein geranylgeranyltransferase activityIEAmolecular_function
GO:0004663Rab geranylgeranyltransferase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005875Microtubule associated complexIDAcellular_component
GO:0005953CAAX-protein geranylgeranyltransferase complexIDAcellular_component
GO:0005965Protein farnesyltransferase complexIDAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008017Microtubule bindingIDAmolecular_function
GO:0008318Protein prenyltransferase activityIEAmolecular_function
GO:0016056Rhodopsin mediated signaling pathwayTASbiological_process
GO:0018342Protein prenylationIEAbiological_process
GO:0018343Protein farnesylationIDAbiological_process
GO:0018344Protein geranylgeranylationIDAbiological_process
GO:0022400Regulation of rhodopsin mediated signaling pathwayTASbiological_process
GO:0030548Acetylcholine receptor regulator activityIEAmolecular_function
GO:0030971Receptor tyrosine kinase bindingIEAmolecular_function
GO:0043014Alpha-tubulin bindingIDAmolecular_function
GO:0045213Neurotransmitter receptor metabolic processIEAbiological_process
GO:0090044Positive regulation of tubulin deacetylationIDAbiological_process
GO:0090045Positive regulation of deacetylase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10099007640.96091223740.66238274921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2272447200
GSE13712_SHEARDown-0.1422904480
GSE13712_STATICDown-0.1082889731
GSE19018Up0.0281200282
GSE19899_A1Up0.4794443661
GSE19899_A2Up0.5315979731
PubMed_21979375_A1Up0.4183641006
PubMed_21979375_A2Up0.4957231485
GSE35957Down-0.2077214431
GSE36640Up0.3776753421
GSE54402Up0.0753859533
GSE9593Up0.0884981279
GSE43922Up0.2707306179
GSE24585Up0.1889631383
GSE37065Up0.0085045378
GSE28863_A1Down-0.0525298484
GSE28863_A2Up0.1846052578
GSE28863_A3Down-0.4030092079
GSE28863_A4Down-0.0097782375
GSE48662Up0.1628570839

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AZD3409DB04893 -
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILEDB06953 -
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINEDB07216 -
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILEDB07227 -
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDB07771 -
FARNESYL DIPHOSPHATEDB07780 -
GERANYLGERANYL DIPHOSPHATEDB07841 -
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDDB07895 -
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATEDB08180 -
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILEDB08674 -
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILEDB08676 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031435ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.