HCSGD entry for SIK3
1. General information
| Official gene symbol | SIK3 |
|---|---|
| Entrez ID | 23387 |
| Gene full name | SIK family kinase 3 |
| Other gene symbols | QSK SIK-3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0032880 | Regulation of protein localization | IEA | biological_process |
| GO:0035108 | Limb morphogenesis | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0060351 | Cartilage development involved in endochondral bone morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0259035523 | 0.9695234756 | 0.3765483444 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2307816307 |
| GSE13712_SHEAR | Down | -0.2967153665 |
| GSE13712_STATIC | Down | -0.0058394525 |
| GSE19018 | Down | -0.0214471404 |
| GSE19899_A1 | Up | 0.0236585034 |
| GSE19899_A2 | Up | 0.2862949839 |
| PubMed_21979375_A1 | Up | 1.1711617862 |
| PubMed_21979375_A2 | Up | 0.8816630459 |
| GSE35957 | Up | 0.3628358259 |
| GSE36640 | Up | 0.1451997161 |
| GSE54402 | Up | 0.6004589647 |
| GSE9593 | Up | 0.1747592208 |
| GSE43922 | Up | 0.4159888376 |
| GSE24585 | Up | 0.3636834771 |
| GSE37065 | Down | -0.0258746946 |
| GSE28863_A1 | Up | 0.4577296517 |
| GSE28863_A2 | Up | 0.3191710336 |
| GSE28863_A3 | Up | 0.0563381540 |
| GSE28863_A4 | Down | -0.1040879153 |
| GSE48662 | Down | -0.2231124371 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-454-3p | MIMAT0003885 | MIRT039234 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
