HCSGD entry for SRGAP2
1. General information
| Official gene symbol | SRGAP2 |
|---|---|
| Entrez ID | 23380 |
| Gene full name | SLIT-ROBO Rho GTPase activating protein 2 |
| Other gene symbols | ARHGAP34 FNBP2 SRGAP2A SRGAP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003363 | Lamellipodium assembly involved in ameboidal cell migration | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA ISS TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0014069 | Postsynaptic density | IEA ISS | cellular_component |
| GO:0021816 | Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration | IEA ISS | biological_process |
| GO:0030027 | Lamellipodium | IDA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030675 | Rac GTPase activator activity | IDA IEA IMP | molecular_function |
| GO:0032855 | Positive regulation of Rac GTPase activity | IDA IMP | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA IEA | molecular_function |
| GO:0044327 | Dendritic spine head | IDA | cellular_component |
| GO:0045211 | Postsynaptic membrane | IEA ISS | cellular_component |
| GO:0045335 | Phagocytic vesicle | IEA ISS | cellular_component |
| GO:0046847 | Filopodium assembly | IDA IEA | biological_process |
| GO:0048365 | Rac GTPase binding | IDA IEA | molecular_function |
| GO:0048812 | Neuron projection morphogenesis | IEA ISS | biological_process |
| GO:0051014 | Actin filament severing | IDA | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0060548 | Negative regulation of cell death | IMP | biological_process |
| GO:0060996 | Dendritic spine development | IDA IEA | biological_process |
| GO:2001223 | Negative regulation of neuron migration | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7950311310 | 0.0587371262 | 0.9999902473 | 0.4564570121 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3040205231 |
| GSE13712_SHEAR | Down | -0.1427741003 |
| GSE13712_STATIC | Up | 0.2388529641 |
| GSE19018 | Up | 0.1169308932 |
| GSE19899_A1 | Down | -0.1334211672 |
| GSE19899_A2 | Down | -0.2679490974 |
| PubMed_21979375_A1 | Down | -0.4180541495 |
| PubMed_21979375_A2 | Down | -0.3026833222 |
| GSE35957 | Down | -0.3878356942 |
| GSE36640 | Down | -0.3307794309 |
| GSE54402 | Up | 0.0930510311 |
| GSE9593 | Down | -0.5158716957 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.6173805957 |
| GSE28863_A2 | Up | 0.6657194545 |
| GSE28863_A3 | Down | -0.8197453080 |
| GSE28863_A4 | Down | -0.3464638093 |
| GSE48662 | Up | 0.2235099907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-214-3p | MIMAT0000271 | MIRT024967 | Reporter assay | Functional MTI | 21276775 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025878 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027717 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045164 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045756 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045795 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
