HCSGD entry for FN1
1. General information
| Official gene symbol | FN1 |
|---|---|
| Entrez ID | 2335 |
| Gene full name | fibronectin 1 |
| Other gene symbols | CIG ED-B FINC FN FNZ GFND GFND2 LETS MSF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | NAS | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0005577 | Fibrinogen complex | IDA | cellular_component |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0006953 | Acute-phase response | IEA | biological_process |
| GO:0007044 | Cell-substrate junction assembly | IEA | biological_process |
| GO:0007155 | Cell adhesion | NAS | biological_process |
| GO:0007161 | Calcium-independent cell-matrix adhesion | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008201 | Heparin binding | NAS | molecular_function |
| GO:0008360 | Regulation of cell shape | IEA | biological_process |
| GO:0009611 | Response to wounding | NAS | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016504 | Peptidase activator activity | IEA | molecular_function |
| GO:0018149 | Peptide cross-linking | IDA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IDA | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1401510315 | 0.1755078606 | 0.7524138487 | 0.8105882436 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1302911595 |
| GSE13712_SHEAR | Down | -0.4529040036 |
| GSE13712_STATIC | Down | -0.2129076190 |
| GSE19018 | Up | 0.1601582671 |
| GSE19899_A1 | Up | 0.2809840620 |
| GSE19899_A2 | Down | -0.3693225990 |
| PubMed_21979375_A1 | Down | -1.3510530033 |
| PubMed_21979375_A2 | Down | -0.3828384422 |
| GSE35957 | Up | 0.5094508134 |
| GSE36640 | Up | 0.4612144374 |
| GSE54402 | Up | 0.0231548014 |
| GSE9593 | Up | 0.3000224039 |
| GSE43922 | Down | -0.0548782850 |
| GSE24585 | Down | -0.5756713426 |
| GSE37065 | Down | -0.0442353147 |
| GSE28863_A1 | Up | 0.2640516552 |
| GSE28863_A2 | Up | 0.3471609760 |
| GSE28863_A3 | Up | 0.4599138271 |
| GSE28863_A4 | Down | -0.4657866469 |
| GSE48662 | Up | 1.1340460931 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ocriplasmin | DB08888 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT006132 | Immunoblot//Immunofluorescence//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22210864 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT003959 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT003959 | Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21501518 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT004009 | Microarray | Functional MTI (Weak) | 17875710 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029079 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040254 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 1713586 | Whereas fibronectin mRNAs from adult rat tissues were found to range from 0 to 25% ED-A+ and from 0 to 10% ED-B+, fibronectin mRNAs from cultured cell lines were found to be approximately 50-60% ED-A+ and 15-25% ED-B+ |
| 1713586 | We demonstrate that serum deprivation; placement of cells into primary culture; and growth factors such as transforming growth factor beta 1, retinoic acid, and 1,25-dihydroxyvitamin D3 can all change the alternative splicing of fibronectin pre-mRNA in the ED-A, ED-B, and type III connecting sequence exons |
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