HCSGD entry for FMR1
1. General information
| Official gene symbol | FMR1 |
|---|---|
| Entrez ID | 2332 |
| Gene full name | fragile X mental retardation 1 |
| Other gene symbols | FMRP FRAXA POF POF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA TAS | molecular_function |
| GO:0003729 | MRNA binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005845 | MRNA cap binding complex | ISS | cellular_component |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IEA | cellular_component |
| GO:0042788 | Polysomal ribosome | TAS | cellular_component |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0043198 | Dendritic shaft | IEA | cellular_component |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0045947 | Negative regulation of translational initiation | ISS | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0071598 | Neuronal ribonucleoprotein granule | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6294793017 | 0.0299926067 | 0.9999902473 | 0.3270237780 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0360189460 |
| GSE13712_SHEAR | Down | -0.1260920050 |
| GSE13712_STATIC | Down | -0.1707298253 |
| GSE19018 | Down | -0.4048993835 |
| GSE19899_A1 | Down | -0.2405929278 |
| GSE19899_A2 | Down | -0.8026020681 |
| PubMed_21979375_A1 | Up | 0.0611705383 |
| PubMed_21979375_A2 | Down | -0.8333374936 |
| GSE35957 | Down | -0.3821819483 |
| GSE36640 | Down | -0.7950786915 |
| GSE54402 | Up | 0.1197823731 |
| GSE9593 | Down | -0.1512096951 |
| GSE43922 | Down | -0.3581139965 |
| GSE24585 | Down | -0.7828145794 |
| GSE37065 | Up | 0.2644126003 |
| GSE28863_A1 | Up | 0.7009227356 |
| GSE28863_A2 | Up | 0.7302907886 |
| GSE28863_A3 | Down | -0.0052173557 |
| GSE28863_A4 | Up | 0.0176721427 |
| GSE48662 | Up | 0.2456105528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT007375 | Luciferase reporter assay | Functional MTI | 23390134 |
| hsa-miR-129-5p | MIMAT0000242 | MIRT007376 | Luciferase reporter assay | Functional MTI | 23390134 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT007377 | Luciferase reporter assay | Functional MTI | 23390134 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030988 | Microarray | Functional MTI (Weak) | 18591254 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18478592 | Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene |
| 18478592 | To test this hypothesis, telomere length has been quantified in T lymphocytes from older male carriers of premutation FMR1 alleles, with or without FXTAS, and FXTAS with dementia |
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