HCSGD entry for FMOD
1. General information
| Official gene symbol | FMOD |
|---|---|
| Entrez ID | 2331 |
| Gene full name | fibromodulin |
| Other gene symbols | SLRR2E |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0007181 | Transforming growth factor beta receptor complex assembly | TAS | biological_process |
| GO:0018146 | Keratan sulfate biosynthetic process | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0042339 | Keratan sulfate metabolic process | TAS | biological_process |
| GO:0042340 | Keratan sulfate catabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0517227423 | 0.0238699821 | 0.4981318332 | 0.2981005218 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0520840277 |
| GSE13712_SHEAR | Up | 0.1284576101 |
| GSE13712_STATIC | Up | 0.0603219242 |
| GSE19018 | Down | -0.7951670550 |
| GSE19899_A1 | Down | -0.4064836051 |
| GSE19899_A2 | Down | -0.1786097716 |
| PubMed_21979375_A1 | Down | -1.2492949640 |
| PubMed_21979375_A2 | Down | -0.6445662154 |
| GSE35957 | Up | 0.2897109127 |
| GSE36640 | Down | -0.5037640356 |
| GSE54402 | Down | -2.4290945267 |
| GSE9593 | Up | 0.6596323566 |
| GSE43922 | Up | 0.0233540696 |
| GSE24585 | Up | 0.1714847063 |
| GSE37065 | Up | 0.9131988815 |
| GSE28863_A1 | Up | 0.0659336803 |
| GSE28863_A2 | Up | 0.9981350994 |
| GSE28863_A3 | Up | 0.8335441653 |
| GSE28863_A4 | Down | -0.3504502324 |
| GSE48662 | Up | 1.1579397761 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT001188 | Western blot | Functional MTI | 19906824 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022505 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16002407 | Fibromodulin gene transcription is induced by ultraviolet irradiation, and its regulation is impaired in senescent human fibroblasts |
| 16002407 | Senescent fibroblasts show significant changes in the expression of mRNAs encoding extracellular matrix-remodeling proteins; among these mRNAs, the mRNA encoding fibromodulin is highly decreased in these cells |
| 16002407 | To understand the molecular basis of this phenomenon, we explored the regulatory mechanisms of the human fibromodulin gene |
| 16002407 | We found that fibromodulin gene promoter contains a cis-element, crucial for its basal expression, that forms a DNA-protein complex when exposed to nuclear extracts from exponentially growing human fibroblasts and not to extracts from cells undergoing senescence by repeated in vitro passages or by mild oxidative stress |
| 16002407 | The latter is known to be induced by UV irradiation; therefore we checked whether fibromodulin gene promoter is regulated upon the exposure of the cells to UV rays |
| 16002407 | Accordingly, in these experimental conditions the endogenous fibromodulin mRNA accumulates to very high levels |
| 16002407 | On the contrary, senescent cells did not show any activation of the fibromodulin gene promoter, any induction of the DDB-1-containing complex, or any accumulation of fibromodulin mRNA |
| 10329479 | The small proteoglycan fibromodulin is expressed in mitotic, but not in postmitotic fibroblasts |
| 10329479 | The small proteoglycan fibromodulin is involved in a variety of adhesion processes of connective tissue, binds to collagen and seems to influence fibrillogenesis by regulating collagen fibril spacing and thickness |
| 10329479 | Using subtractive hybridisation and Northern blotting, we found expression of the fibromodulin gene only in mitotic but not in mitomycinC-induced postmitotic fibroblasts |
| 10329479 | Furthermore, we could show that in skin only fibroblasts but not endothelial cells and keratinocytes express fibromodulin |
| 10329479 | Therefore, fibromodulin provides a specific marker for mitotic versus postmitotic fibroblasts and could indicate cell ageing |
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