HCSGD entry for SMG6
1. General information
| Official gene symbol | SMG6 |
|---|---|
| Entrez ID | 23293 |
| Gene full name | smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) |
| Other gene symbols | C17orf31 EST1A SMG-6 hSMG5/7a |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | IMP TAS | biological_process |
| GO:0000723 | Telomere maintenance | IMP | biological_process |
| GO:0000781 | Chromosome, telomeric region | IEA | cellular_component |
| GO:0004521 | Endoribonuclease activity | IDA IMP TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005697 | Telomerase holoenzyme complex | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0035145 | Exon-exon junction complex | IDA | cellular_component |
| GO:0035303 | Regulation of dephosphorylation | TAS | biological_process |
| GO:0042162 | Telomeric DNA binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA IMP TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IDA IMP TAS | biological_process |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | IDA IMP TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0806364652 | 0.9761139622 | 0.5983739498 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0519373347 |
| GSE13712_SHEAR | Up | 0.3138298795 |
| GSE13712_STATIC | Up | 0.4111144762 |
| GSE19018 | Up | 0.1103577971 |
| GSE19899_A1 | Up | 0.0758403405 |
| GSE19899_A2 | Up | 0.4002746662 |
| PubMed_21979375_A1 | Up | 0.4731053194 |
| PubMed_21979375_A2 | Up | 0.5951747675 |
| GSE35957 | Down | -0.0404017197 |
| GSE36640 | Down | -0.0533508790 |
| GSE54402 | Up | 0.3237929151 |
| GSE9593 | Up | 0.0159082504 |
| GSE43922 | Up | 0.0483849337 |
| GSE24585 | Up | 0.1330570460 |
| GSE37065 | Down | -0.0103825427 |
| GSE28863_A1 | Up | 0.4168216326 |
| GSE28863_A2 | Up | 0.1667385311 |
| GSE28863_A3 | Down | -0.0686776592 |
| GSE28863_A4 | Down | -0.0017122912 |
| GSE48662 | Up | 0.3373137908 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Grn163l | DB05036 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029580 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043517 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045363 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048902 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
