HCSGD entry for FBXW11
1. General information
| Official gene symbol | FBXW11 |
|---|---|
| Entrez ID | 23291 |
| Gene full name | F-box and WD repeat domain containing 11 |
| Other gene symbols | BTRC2 BTRCP2 FBW1B FBXW1B Fbw11 Hos |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | NAS | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | ISS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA NAS | biological_process |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | cellular_component |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0031648 | Protein destabilization | IMP | biological_process |
| GO:0042347 | Negative regulation of NF-kappaB import into nucleus | IEA | biological_process |
| GO:0042753 | Positive regulation of circadian rhythm | ISS | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0045862 | Positive regulation of proteolysis | IMP | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0048511 | Rhythmic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0665910490 | 0.9590139660 | 0.5559707580 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1513888402 |
| GSE13712_SHEAR | Down | -0.1058490226 |
| GSE13712_STATIC | Up | 0.0799463400 |
| GSE19018 | Up | 0.2042455754 |
| GSE19899_A1 | Up | 0.1586490115 |
| GSE19899_A2 | Up | 0.7058321986 |
| PubMed_21979375_A1 | Down | -0.1054680980 |
| PubMed_21979375_A2 | Up | 0.1673433505 |
| GSE35957 | Up | 0.6176632867 |
| GSE36640 | Up | 0.3141394514 |
| GSE54402 | Up | 0.3194944581 |
| GSE9593 | Up | 0.5020819738 |
| GSE43922 | Up | 0.0157910545 |
| GSE24585 | Down | -0.0352158299 |
| GSE37065 | Up | 0.0627750102 |
| GSE28863_A1 | Down | -0.1330073851 |
| GSE28863_A2 | Down | -0.0656296439 |
| GSE28863_A3 | Down | -0.3004970545 |
| GSE28863_A4 | Up | 0.0688003937 |
| GSE48662 | Up | 0.7502403536 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019282 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-450a-5p | MIMAT0001545 | MIRT042396 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051087 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
