HCSGD entry for EXOC7
1. General information
| Official gene symbol | EXOC7 |
|---|---|
| Entrez ID | 23265 |
| Gene full name | exocyst complex component 7 |
| Other gene symbols | 2-5-3p EX070 EXO70 EXOC1 Exo70p YJL085W |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000145 | Exocyst | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005815 | Microtubule organizing center | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006887 | Exocytosis | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0032584 | Growth cone membrane | IEA | cellular_component |
| GO:0034451 | Centriolar satellite | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1419911516 | 0.9277589871 | 0.7565484008 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0716341628 |
| GSE13712_SHEAR | Up | 0.2404247043 |
| GSE13712_STATIC | Up | 0.2478663563 |
| GSE19018 | Down | -0.0928434859 |
| GSE19899_A1 | Down | -0.0651808350 |
| GSE19899_A2 | Up | 0.1496150944 |
| PubMed_21979375_A1 | Down | -0.1364548842 |
| PubMed_21979375_A2 | Up | 0.0547933044 |
| GSE35957 | Up | 0.0357958710 |
| GSE36640 | Up | 0.5393454477 |
| GSE54402 | Up | 0.1146110709 |
| GSE9593 | Up | 0.0308547398 |
| GSE43922 | Down | -0.0480001846 |
| GSE24585 | Up | 0.4762574989 |
| GSE37065 | Up | 0.0700975993 |
| GSE28863_A1 | Up | 0.3945880642 |
| GSE28863_A2 | Up | 0.2487081312 |
| GSE28863_A3 | Up | 0.2662170307 |
| GSE28863_A4 | Down | -0.0869516306 |
| GSE48662 | Down | -0.0655849519 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020501 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040126 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040867 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043463 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045968 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21639856 | Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing |
| 21639856 | In the present paper we report that Exo70 interacts directly with SNEV(hPrp19/hPso4) and shuttles to the nucleus, where it associates with the spliceosome |
| 21639856 | We mapped the interaction site to the N-terminal 100 amino acids of Exo70, which interfere with pre-mRNA splicing in vitro |
| 21639856 | Furthermore, Exo70 influences the splicing of a model substrate as well as of its own pre-mRNA in vivo |
| 21639856 | In addition, we found that Exo70 is alternatively spliced in a cell-type- and cell-age- dependent way |
| 21639856 | These results suggest a novel and unexpected role of Exo70 in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus |
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