HCSGD entry for SIK2
1. General information
| Official gene symbol | SIK2 |
|---|---|
| Entrez ID | 23235 |
| Gene full name | salt-inducible kinase 2 |
| Other gene symbols | LOH11CR1I QIK SNF1LK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0046626 | Regulation of insulin receptor signaling pathway | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3092352912 | 0.5375322518 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1535922028 |
| GSE13712_SHEAR | Down | -0.2004005890 |
| GSE13712_STATIC | Down | -0.1029357178 |
| GSE19018 | Up | 0.3666032268 |
| GSE19899_A1 | Down | -0.0340146666 |
| GSE19899_A2 | Down | -0.0763880304 |
| PubMed_21979375_A1 | Up | 0.0468309143 |
| PubMed_21979375_A2 | Up | 0.2564406367 |
| GSE35957 | Up | 0.2208588443 |
| GSE36640 | Down | -0.1462554940 |
| GSE54402 | Up | 0.0435043248 |
| GSE9593 | Down | -0.0390304888 |
| GSE43922 | Up | 0.0014553540 |
| GSE24585 | Up | 0.0280733890 |
| GSE37065 | Up | 0.3386548276 |
| GSE28863_A1 | Up | 0.6994547496 |
| GSE28863_A2 | Up | 0.4824279248 |
| GSE28863_A3 | Down | -0.2582438185 |
| GSE28863_A4 | Down | -0.1615464177 |
| GSE48662 | Down | -0.1642095467 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036375 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045926 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047302 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20528770 | In contrast, up-regulation of Nuak2 (NUAK family, SNF1-like kinase 2) and down-regulation of Lonp2 (Lon peptidase 2), Foxo3a (forkhead box O3a), Sod1 (copper/zinc superoxide dismutase) and Sesn1 (sestrin 1) in the kidneys of recuperated offspring suggest that protein homoeostasis and resistance to oxidative stress are compromised, leading to accelerated cellular senescence in these shorter-lived mice |
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