HCSGD entry for XPO6
1. General information
| Official gene symbol | XPO6 |
|---|---|
| Entrez ID | 23214 |
| Gene full name | exportin 6 |
| Other gene symbols | EXP6 RANBP20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IC IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006611 | Protein export from nucleus | IDA | biological_process |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0008536 | Ran GTPase binding | IEA | molecular_function |
| GO:0008565 | Protein transporter activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5783346909 | 0.2198716196 | 0.9999902473 | 0.9027048666 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3153013541 |
| GSE13712_SHEAR | Up | 0.3400947909 |
| GSE13712_STATIC | Up | 0.1847738113 |
| GSE19018 | Down | -0.4267656156 |
| GSE19899_A1 | Down | -0.6092012981 |
| GSE19899_A2 | Up | 0.0092907212 |
| PubMed_21979375_A1 | Up | 0.9737233251 |
| PubMed_21979375_A2 | Up | 0.5120345628 |
| GSE35957 | Down | -0.0008927142 |
| GSE36640 | Down | -0.2953921510 |
| GSE54402 | Up | 0.2209731766 |
| GSE9593 | Down | -0.0182646302 |
| GSE43922 | Down | -0.0320688771 |
| GSE24585 | Down | -0.2716912381 |
| GSE37065 | Down | -0.1256191927 |
| GSE28863_A1 | Down | -0.0376405704 |
| GSE28863_A2 | Up | 0.2172116940 |
| GSE28863_A3 | Down | -0.1630101505 |
| GSE28863_A4 | Up | 0.0657696093 |
| GSE48662 | Up | 0.1382913666 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002751 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002751 | Immunoblot//Immunofluorescence//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22210864 |
| hsa-miR-1 | MIMAT0000416 | MIRT002751 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003106 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043121 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044849 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045379 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046690 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051247 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21195711 | Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells |
| 21195711 | Expression of exportin 6 (Exp6) and small G-protein, Ran, was significantly reduced in the replicative senescence, but not yet in SIPS, whereas nuclear import of actin by cofilin was already increased in SIPS |
| 21195711 | Furthermore, significantly reduced interaction of Exp6 with RanGTP was found by GST-Exp6 pull-down analysis |
| 21195711 | Indeed, knockdown of Exp6 expression significantly increased actin molecule in the nuclei of young HDF cells |
| 21195711 | Therefore, actin accumulation in nuclei of senescent cells is most likely due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation in nuclei, which result in the decrease of actin export via Exp6 inactivation, in addition to actin import by cofilin activation |
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