HCSGD entry for SULF1

1. General information

Official gene symbolSULF1
Entrez ID23213
Gene full namesulfatase 1
Other gene symbolsHSULF-1 SULF-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentISSbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0002063Chondrocyte developmentIEA ISSbiological_process
GO:0003094Glomerular filtrationIEA ISSbiological_process
GO:0003824Catalytic activityIEAmolecular_function
GO:0004065Arylsulfatase activityIDA IMPmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005615Extracellular spaceIDA NAScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005795Golgi stackIEAcellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0008449N-acetylglucosamine-6-sulfatase activityIDA IMPmolecular_function
GO:0008484Sulfuric ester hydrolase activityIEAmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0010575Positive regulation vascular endothelial growth factor productionIEA ISSbiological_process
GO:0014846Esophagus smooth muscle contractionIEA ISSbiological_process
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030201Heparan sulfate proteoglycan metabolic processIDA IEA NASbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIMPbiological_process
GO:0032836Glomerular basement membrane developmentIEA ISSbiological_process
GO:0035860Glial cell-derived neurotrophic factor receptor signaling pathwayIEA ISSbiological_process
GO:0040036Regulation of fibroblast growth factor receptor signaling pathwayIMPbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEA IMP ISSbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIDAbiological_process
GO:0048706Embryonic skeletal system developmentIEA ISSbiological_process
GO:0051216Cartilage developmentISSbiological_process
GO:0060348Bone developmentIEA ISSbiological_process
GO:0060384InnervationIEA ISSbiological_process
GO:0060686Negative regulation of prostatic bud formationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98588297180.00000805440.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.9071674841
GSE13712_SHEARDown-6.2437205891
GSE13712_STATICDown-1.8463238677
GSE19018Down-0.3095141912
GSE19899_A1Down-2.2148652255
GSE19899_A2Down-1.7887701565
PubMed_21979375_A1Down-5.4895678910
PubMed_21979375_A2Down-6.2556719401
GSE35957Up0.0707942349
GSE36640Down-2.9567974517
GSE54402Down-2.9259102244
GSE9593Down-0.7518142334
GSE43922Down-1.6996299691
GSE24585Down-0.5546538126
GSE37065Up0.6506835815
GSE28863_A1Down-0.2743673948
GSE28863_A2Up0.5257335780
GSE28863_A3Down-0.3761984443
GSE28863_A4Down-0.2591670515
GSE48662Down-0.1224093414

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-516a-3pMIMAT0006778MIRT005970Northern blot//qRT-PCR//Western blotFunctional MTI21169410
hsa-miR-124-3pMIMAT0000422MIRT022965MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-516a-5pMIMAT0004770NAhsa-miR-516a-5p{Western blot}{overexpression}21169410
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.