HCSGD entry for FLOT2
1. General information
| Official gene symbol | FLOT2 |
|---|---|
| Entrez ID | 2319 |
| Gene full name | flotillin 2 |
| Other gene symbols | ECS-1 ECS1 ESA ESA1 M17S1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002080 | Acrosomal membrane | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | NAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0016600 | Flotillin complex | IEA | cellular_component |
| GO:0030139 | Endocytic vesicle | IDA | cellular_component |
| GO:0035255 | Ionotropic glutamate receptor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0502459709 | 0.7598620189 | 0.4905505193 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0014413874 |
| GSE13712_SHEAR | Down | -0.4158205470 |
| GSE13712_STATIC | Down | -0.6476566350 |
| GSE19018 | Up | 0.2491069310 |
| GSE19899_A1 | Down | -0.1046600473 |
| GSE19899_A2 | Up | 0.3762145115 |
| PubMed_21979375_A1 | Up | 0.3373321121 |
| PubMed_21979375_A2 | Up | 1.0661060439 |
| GSE35957 | Up | 0.4387139480 |
| GSE36640 | Up | 0.4603790385 |
| GSE54402 | Down | -0.2164685375 |
| GSE9593 | Up | 0.3923554884 |
| GSE43922 | Up | 0.0374587320 |
| GSE24585 | Down | -0.3631649425 |
| GSE37065 | Down | -0.1025851556 |
| GSE28863_A1 | Up | 0.1609795199 |
| GSE28863_A2 | Up | 0.4255865259 |
| GSE28863_A3 | Up | 0.3400109899 |
| GSE28863_A4 | Up | 0.1981028379 |
| GSE48662 | Up | 0.2377243447 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019295 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022325 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023557 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023557 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042495 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17427253 | On the basis of the known structure of flotillin-2, another member of the SPFH-domain family, we have generated homology models for BAP32 and BAP37, and elucidated the implications for formation of high molecular weight oligomers |
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