HCSGD entry for METAP1
1. General information
| Official gene symbol | METAP1 |
|---|---|
| Entrez ID | 23173 |
| Gene full name | methionyl aminopeptidase 1 |
| Other gene symbols | MAP1A MetAP1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004177 | Aminopeptidase activity | IEA TAS | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006417 | Regulation of translation | TAS | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008235 | Metalloexopeptidase activity | IEA TAS | molecular_function |
| GO:0016056 | Rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0018206 | Peptidyl-methionine modification | TAS | biological_process |
| GO:0022400 | Regulation of rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0031365 | N-terminal protein amino acid modification | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7985237339 | 0.0757937502 | 0.9999902473 | 0.5196580620 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8094078278 |
| GSE13712_SHEAR | Up | 0.0907724349 |
| GSE13712_STATIC | Up | 0.1295917998 |
| GSE19018 | Down | -0.2279745785 |
| GSE19899_A1 | Up | 0.3002579745 |
| GSE19899_A2 | Up | 0.1573111456 |
| PubMed_21979375_A1 | Up | 0.4346431351 |
| PubMed_21979375_A2 | Up | 0.2658767994 |
| GSE35957 | Down | -0.0445051377 |
| GSE36640 | Down | -0.8368405440 |
| GSE54402 | Up | 0.1287683790 |
| GSE9593 | Down | -0.3243814782 |
| GSE43922 | Up | 0.0011631919 |
| GSE24585 | Down | -0.1789903507 |
| GSE37065 | Up | 0.0598182862 |
| GSE28863_A1 | Up | 0.1054583741 |
| GSE28863_A2 | Down | -0.0164098566 |
| GSE28863_A3 | Down | -0.4777307144 |
| GSE28863_A4 | Down | -0.1795071718 |
| GSE48662 | Down | -0.7985021768 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ovalicin | DB04324 | EXPT02454 |
| 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE | DB07901 | - |
| TERT-BUTYL {2-[(1,3-THIAZOL-2-YLAMINO)CARBONYL]PYRIDIN-3-YL}CARBAMATE | DB07902 | - |
| 3-[(2,2-DIMETHYLPROPANOYL)AMINO]-N-1,3-THIAZOL-2-YLPYRIDINE-2-CARBOXAMIDE | DB07903 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025186 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025578 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
