HCSGD entry for RTF1
1. General information
| Official gene symbol | RTF1 |
|---|---|
| Entrez ID | 23168 |
| Gene full name | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) |
| Other gene symbols | GTL7 KIAA0252 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0001711 | Endodermal cell fate commitment | ISS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0006352 | DNA-templated transcription, initiation | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016570 | Histone modification | IEA | biological_process |
| GO:0016593 | Cdc73/Paf1 complex | IDA | cellular_component |
| GO:0019827 | Stem cell maintenance | IDA | biological_process |
| GO:0032968 | Positive regulation of transcription elongation from RNA polymerase II promoter | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0051571 | Positive regulation of histone H3-K4 methylation | IEA | biological_process |
| GO:0080182 | Histone H3-K4 trimethylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3829082710 | 0.3815755594 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0021576528 |
| GSE13712_SHEAR | Down | -0.3213541652 |
| GSE13712_STATIC | Down | -0.2017616568 |
| GSE19018 | Up | 0.0234470463 |
| GSE19899_A1 | Down | -0.2267880481 |
| GSE19899_A2 | Down | -0.1359534288 |
| PubMed_21979375_A1 | Down | -0.3719252554 |
| PubMed_21979375_A2 | Down | -0.1589098249 |
| GSE35957 | Down | -0.0742829025 |
| GSE36640 | Down | -0.1453713173 |
| GSE54402 | Up | 0.0694472049 |
| GSE9593 | Up | 0.0521921518 |
| GSE43922 | Down | -0.3319772485 |
| GSE24585 | Up | 0.0267942927 |
| GSE37065 | Up | 0.0731156578 |
| GSE28863_A1 | Up | 0.8732933558 |
| GSE28863_A2 | Up | 0.8164966840 |
| GSE28863_A3 | Up | 0.1557456509 |
| GSE28863_A4 | Up | 0.3230268721 |
| GSE48662 | Down | -0.2328366094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029127 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042673 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
