HCSGD entry for ANKLE2
1. General information
| Official gene symbol | ANKLE2 |
|---|---|
| Entrez ID | 23141 |
| Gene full name | ankyrin repeat and LEM domain containing 2 |
| Other gene symbols | KIAA0692 LEMD7 Lem4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007084 | Mitotic nuclear envelope reassembly | IMP TAS | biological_process |
| GO:0008601 | Protein phosphatase type 2A regulator activity | TAS | molecular_function |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0035307 | Positive regulation of protein dephosphorylation | IDA | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0051721 | Protein phosphatase 2A binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0974655826 | 0.8810056077 | 0.6529301527 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3467166647 |
| GSE13712_SHEAR | Up | 0.5377956361 |
| GSE13712_STATIC | Up | 0.1398454353 |
| GSE19018 | Down | -0.5367034275 |
| GSE19899_A1 | Up | 0.0632567777 |
| GSE19899_A2 | Up | 0.0000405710 |
| PubMed_21979375_A1 | Up | 0.3696049710 |
| PubMed_21979375_A2 | Up | 0.3725767831 |
| GSE35957 | Up | 0.1454393841 |
| GSE36640 | Up | 0.3307449387 |
| GSE54402 | Up | 0.1982637810 |
| GSE9593 | Up | 0.2932573680 |
| GSE43922 | Up | 0.4232000765 |
| GSE24585 | Up | 0.0597866060 |
| GSE37065 | Down | -0.0704188914 |
| GSE28863_A1 | Up | 0.3773976960 |
| GSE28863_A2 | Up | 0.3797895213 |
| GSE28863_A3 | Down | -0.0672839800 |
| GSE28863_A4 | Up | 0.0222533393 |
| GSE48662 | Down | -0.0917263788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031684 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049020 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
