HCSGD entry for PHF8

1. General information

Official gene symbolPHF8
Entrez ID23133
Gene full namePHD finger protein 8
Other gene symbolsJHDM1F MRXSSD ZNF422
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0007420Brain developmentISSbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0032452Histone demethylase activityIDAmolecular_function
GO:0071558Histone demethylase activity (H3-K27 specific)IDAmolecular_function
GO:0051864Histone demethylase activity (H3-K36 specific)IDAmolecular_function
GO:0032454Histone demethylase activity (H3-K9 specific)IDAmolecular_function
GO:0035575Histone demethylase activity (H4-K20 specific)IDAmolecular_function
GO:0071557Histone H3-K27 demethylationIDAbiological_process
GO:0070544Histone H3-K36 demethylationIDAbiological_process
GO:0033169Histone H3-K9 demethylationIDAbiological_process
GO:0035574Histone H4-K20 demethylationIDAbiological_process
GO:0005506Iron ion bindingIDAmolecular_function
GO:0035064Methylated histone residue bindingIDAmolecular_function
GO:0061188Negative regulation of chromatin silencing at rDNAIDAbiological_process
GO:0005730NucleolusIDAcellular_component
GO:0005634NucleusIC IDAcellular_component
GO:0016706Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsIDAmolecular_function
GO:0045943Positive regulation of transcription from RNA polymerase I promoterIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43463259370.92181593400.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0324203632
GSE13712_SHEARDown-0.1253196603
GSE13712_STATICDown-0.2162559198
GSE19018Down-0.0746387042
GSE19899_A1Up0.0421170668
GSE19899_A2Up0.0786700879
PubMed_21979375_A1Up0.1336667917
PubMed_21979375_A2Up0.1078976909
GSE35957Down-0.0031440357
GSE36640Down-0.0631903412
GSE54402Up0.0015049944
GSE9593Down-0.1023439838
GSE43922Up0.0701340673
GSE24585Up0.0606793089
GSE37065Up0.0077113922
GSE28863_A1Up0.4762600917
GSE28863_A2Up0.5036772402
GSE28863_A3Up0.0539435915
GSE28863_A4Up0.0247214733
GSE48662Up0.1076887272

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-20a-5pMIMAT0000075MIRT050476CLASHFunctional MTI (Weak)23622248
hsa-miR-335-5pMIMAT0000765MIRT019133MicroarrayFunctional MTI (Weak)18185580
hsa-miR-193b-3pMIMAT0002819MIRT041284CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037650CLASHFunctional MTI (Weak)23622248
hsa-miR-1229-3pMIMAT0005584MIRT036321CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.