HCSGD entry for HIC2
1. General information
| Official gene symbol | HIC2 |
|---|---|
| Entrez ID | 23119 |
| Gene full name | hypermethylated in cancer 2 |
| Other gene symbols | HRG22 ZBTB30 ZNF907 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1684257513 | 0.9238065347 | 0.8090845060 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0128286748 |
| GSE13712_SHEAR | Up | 0.2736458603 |
| GSE13712_STATIC | Up | 0.2012098609 |
| GSE19018 | Up | 0.0026660405 |
| GSE19899_A1 | Up | 0.0643235517 |
| GSE19899_A2 | Up | 0.5557434674 |
| PubMed_21979375_A1 | Up | 0.7900487631 |
| PubMed_21979375_A2 | Up | 0.5813861149 |
| GSE35957 | Down | -0.5526349139 |
| GSE36640 | Down | -0.1068744696 |
| GSE54402 | Up | 0.1736985203 |
| GSE9593 | Down | -0.0595744116 |
| GSE43922 | Up | 0.2532280606 |
| GSE24585 | Up | 0.1310011791 |
| GSE37065 | Up | 0.0669259741 |
| GSE28863_A1 | Down | -0.0493633050 |
| GSE28863_A2 | Down | -0.1251042326 |
| GSE28863_A3 | Up | 0.2600404504 |
| GSE28863_A4 | Down | -0.0976796986 |
| GSE48662 | Down | -0.0426675437 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-5p | MIMAT0003886 | MIRT016094 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023435 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030600 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-28-3p | MIMAT0004502 | MIRT038944 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042187 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043900 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
