HCSGD entry for NMNAT2
1. General information
| Official gene symbol | NMNAT2 |
|---|---|
| Entrez ID | 23057 |
| Gene full name | nicotinamide nucleotide adenylyltransferase 2 |
| Other gene symbols | C1orf15 PNAT2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000309 | Nicotinamide-nucleotide adenylyltransferase activity | TAS | molecular_function |
| GO:0004515 | Nicotinate-nucleotide adenylyltransferase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005770 | Late endosome | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IEA | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0009435 | NAD biosynthetic process | IC IEA | biological_process |
| GO:0019674 | NAD metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045202 | Synapse | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0101305611 | 0.9858538733 | 0.2561445725 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3693358827 |
| GSE13712_SHEAR | Up | 0.0987026330 |
| GSE13712_STATIC | Up | 0.0825610800 |
| GSE19018 | Up | 0.4435078551 |
| GSE19899_A1 | Up | 0.0978946989 |
| GSE19899_A2 | Up | 0.7821140855 |
| PubMed_21979375_A1 | Up | 1.1298225998 |
| PubMed_21979375_A2 | Up | 0.2760036900 |
| GSE35957 | Up | 0.6776434298 |
| GSE36640 | Up | 0.7363184258 |
| GSE54402 | Up | 0.6266689959 |
| GSE9593 | Up | 0.5827418200 |
| GSE43922 | Up | 0.1065311853 |
| GSE24585 | Up | 0.2552209657 |
| GSE37065 | Down | -0.0308645001 |
| GSE28863_A1 | Down | -0.3429512650 |
| GSE28863_A2 | Up | 0.0105721649 |
| GSE28863_A3 | Up | 0.1311956705 |
| GSE28863_A4 | Up | 0.1499514274 |
| GSE48662 | Down | -0.1332672092 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021432 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023309 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040033 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20457531 | In humans, three isozymes have been identified: NMNAT1, which is widely expressed in all tissues, NMNAT2 and NMNAT3, which show a tissue-specific expression and whose mRNA levels are generally lower compared to NMNAT1 |
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