HCSGD entry for KDM4B
1. General information
| Official gene symbol | KDM4B |
|---|---|
| Entrez ID | 23030 |
| Gene full name | lysine (K)-specific demethylase 4B |
| Other gene symbols | JMJD2B TDRD14B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0051213 | Dioxygenase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1508345048 | 0.8950141522 | 0.7758350918 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4572433072 |
| GSE13712_SHEAR | Down | -0.1001298263 |
| GSE13712_STATIC | Down | -0.0832880895 |
| GSE19018 | Up | 0.4774213074 |
| GSE19899_A1 | Up | 0.0214051414 |
| GSE19899_A2 | Up | 0.7603878321 |
| PubMed_21979375_A1 | Up | 0.3714166494 |
| PubMed_21979375_A2 | Up | 0.4357814125 |
| GSE35957 | Up | 0.0490865489 |
| GSE36640 | Up | 0.1361925195 |
| GSE54402 | Down | -0.0041991125 |
| GSE9593 | Up | 0.0985719835 |
| GSE43922 | Up | 0.0949495549 |
| GSE24585 | Up | 0.0272110533 |
| GSE37065 | Down | -0.1963078437 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.5234240224 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018784 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-505-5p | MIMAT0004776 | MIRT037961 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038564 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040426 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27114850 | HIF-1alpha stimulates the expression of KDM3A, KDM4B, KDM4C, and KDM6B, which enhance gene transcription by demethylating H3K9 and H3K27 sites (repressive epigenetic marks) |
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