HCSGD entry for CNOT1
1. General information
| Official gene symbol | CNOT1 |
|---|---|
| Entrez ID | 23019 |
| Gene full name | CCR4-NOT transcription complex, subunit 1 |
| Other gene symbols | CDC39 NOT1 NOT1H |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000932 | Cytoplasmic mRNA processing body | IDA ISS | cellular_component |
| GO:0004535 | Poly(A)-specific ribonuclease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005778 | Peroxisomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010606 | Positive regulation of cytoplasmic mRNA processing body assembly | IDA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0030331 | Estrogen receptor binding | IDA | molecular_function |
| GO:0031047 | Gene silencing by RNA | IEA | biological_process |
| GO:0033147 | Negative regulation of intracellular estrogen receptor signaling pathway | IDA | biological_process |
| GO:0042974 | Retinoic acid receptor binding | IDA | molecular_function |
| GO:0048387 | Negative regulation of retinoic acid receptor signaling pathway | IDA | biological_process |
| GO:0060213 | Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | IMP | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IDA | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IDA | biological_process |
| GO:1900153 | Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IMP | biological_process |
| GO:2000036 | Regulation of stem cell maintenance | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1056269443 | 0.8616166293 | 0.6747038583 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0761545713 |
| GSE13712_SHEAR | Up | 0.1741256046 |
| GSE13712_STATIC | Up | 0.1206133176 |
| GSE19018 | Up | 0.1233665418 |
| GSE19899_A1 | Up | 0.0450429828 |
| GSE19899_A2 | Up | 0.2331733106 |
| PubMed_21979375_A1 | Up | 0.4105169197 |
| PubMed_21979375_A2 | Up | 0.6328019016 |
| GSE35957 | Down | -0.0834932389 |
| GSE36640 | Down | -0.2918638163 |
| GSE54402 | Up | 0.2941612758 |
| GSE9593 | Down | -0.0125254197 |
| GSE43922 | Down | -0.0001338628 |
| GSE24585 | Up | 0.0681975194 |
| GSE37065 | Down | -0.0652130845 |
| GSE28863_A1 | Up | 0.5744469901 |
| GSE28863_A2 | Up | 0.6520788679 |
| GSE28863_A3 | Down | -0.5866714077 |
| GSE28863_A4 | Up | 0.1145087199 |
| GSE48662 | Down | -0.1227329257 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037620 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038795 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039055 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-454-3p | MIMAT0003885 | MIRT039246 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039422 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039634 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041221 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042519 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT044167 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045861 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046901 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049821 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052277 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
