HCSGD entry for NT5C2
1. General information
| Official gene symbol | NT5C2 |
|---|---|
| Entrez ID | 22978 |
| Gene full name | 5'-nucleotidase, cytosolic II |
| Other gene symbols | GMP NT5B PNT5 cN-II |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006195 | Purine nucleotide catabolic process | TAS | biological_process |
| GO:0008253 | 5'-nucleotidase activity | EXP | molecular_function |
| GO:0016310 | Phosphorylation | TAS | biological_process |
| GO:0016311 | Dephosphorylation | EXP TAS | biological_process |
| GO:0017144 | Drug metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050146 | Nucleoside phosphotransferase activity | TAS | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4776953725 | 0.2413438053 | 0.9999902473 | 0.9458801370 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1378046469 |
| GSE13712_SHEAR | Up | 0.1375874178 |
| GSE13712_STATIC | Up | 0.0989419896 |
| GSE19018 | Down | -0.1123620904 |
| GSE19899_A1 | Down | -0.2315944192 |
| GSE19899_A2 | Up | 0.1880880797 |
| PubMed_21979375_A1 | Down | -0.3938803055 |
| PubMed_21979375_A2 | Down | -0.1245288934 |
| GSE35957 | Up | 0.6149085463 |
| GSE36640 | Up | 0.3204451716 |
| GSE54402 | Down | -0.3269797594 |
| GSE9593 | Up | 0.2516001203 |
| GSE43922 | Down | -0.3091419842 |
| GSE24585 | Up | 0.0035341949 |
| GSE37065 | Down | -0.0860978108 |
| GSE28863_A1 | Down | -0.2232305457 |
| GSE28863_A2 | Up | 0.1473173330 |
| GSE28863_A3 | Down | -0.6600548353 |
| GSE28863_A4 | Up | 0.2440747125 |
| GSE48662 | Up | 0.5575169207 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
| Ribavirin | DB00811 | APRD00081 | EXPT02825 | DB01693 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT020065 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025290 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031022 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041471 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24755407 | We have recently described an Epigenetic-Senescence-Signature that facilitates prediction of the state of cellular aging by analysis of DNAm at six CpG sites (associated with the genes GRM7, CASR, PRAMEF2, SELP, CASP14 and KRTAP13-3), but this has not yet been proven over subsequent passages and with MSCs isolated under good manufacturing practice (GMP) conditions |
| 12669367 | The results demonstrate that cell cultures derived from eight-day old regenerated endothelium exhibit a normal basal production of cyclic GMP, but a reduced response to bradykinin or the Ca2+ ionophore A23187 |
| 12669367 | With multiple cellular passages, used to mimick aging, the basal production of cyclic GMP remained stable during the first passage, to decrease moderately after one month (4th passage) |
Entries Per Page
Displaying Page of
