HCSGD entry for P2RX2

1. General information

Official gene symbolP2RX2
Entrez ID22953
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 2
Other gene symbolsDFNA41 P2X2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIBA IEA NASmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0003029Detection of hypoxic conditions in blood by carotid body chemoreceptor signalingIEAbiological_process
GO:0004931Extracellular ATP-gated cation channel activityIBA NASmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005524ATP bindingIEA NASmolecular_function
GO:0006812Cation transportIBAbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009743Response to carbohydrateIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010524Positive regulation of calcium ion transport into cytosolNASbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0014832Urinary bladder smooth muscle contractionIEAbiological_process
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0016020MembraneIBA IEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016151Nickel cation bindingIEAmolecular_function
GO:0019228Neuronal action potentialIEAbiological_process
GO:0030432PeristalsisIEAbiological_process
GO:0033198Response to ATPIEAbiological_process
GO:0034220Ion transmembrane transportIBA NAS TASbiological_process
GO:0035091Phosphatidylinositol bindingIEAmolecular_function
GO:0035587Purinergic receptor signaling pathwayIBA NASbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIBA NASbiological_process
GO:0042734Presynaptic membraneIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043235Receptor complexIDAcellular_component
GO:0045340Mercury ion bindingIEAmolecular_function
GO:0046870Cadmium ion bindingIEAmolecular_function
GO:0048266Behavioral response to painIEAbiological_process
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingNASbiological_process
GO:0050897Cobalt ion bindingIEAmolecular_function
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0051260Protein homooligomerizationIPIbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0055085Transmembrane transportIBA NAS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31567527450.94369223050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1129318838
GSE13712_SHEARDown-0.1017001647
GSE13712_STATICUp0.0042807262
GSE19018Up0.0796162120
GSE19899_A1Up0.0213223053
GSE19899_A2Up0.1900308543
PubMed_21979375_A1Up0.0209236415
PubMed_21979375_A2Down-0.0549685584
GSE35957Up0.1425840426
GSE36640Up0.1362083360
GSE54402Up0.0002778093
GSE9593Up0.0271169905
GSE43922Up0.0436866849
GSE24585Up0.2492541096
GSE37065Down-0.0363079120
GSE28863_A1Down-0.0563863181
GSE28863_A2Up0.0600563217
GSE28863_A3Up0.4752131721
GSE28863_A4Up0.2386094099
GSE48662Up0.2730396934

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030048MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.