HCSGD entry for SHANK2

1. General information

Official gene symbolSHANK2
Entrez ID22941
Gene full nameSH3 and multiple ankyrin repeat domains 2
Other gene symbolsAUTS17 CORTBP1 CTTNBP1 ProSAP1 SHANK SPANK-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001750Photoreceptor outer segmentIEA ISScellular_component
GO:0001917Photoreceptor inner segmentIEA ISScellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005883NeurofilamentIEA ISScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0007416Synapse assemblyISSbiological_process
GO:0007612LearningIMPbiological_process
GO:0008328Ionotropic glutamate receptor complexIEA ISScellular_component
GO:0014069Postsynaptic densityISScellular_component
GO:0016324Apical plasma membraneISScellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030160GKAP/Homer scaffold activityNASmolecular_function
GO:0030426Growth coneISScellular_component
GO:0030534Adult behaviorIMPbiological_process
GO:0031526Brush border membraneISScellular_component
GO:0035176Social behaviorIMPbiological_process
GO:0035255Ionotropic glutamate receptor bindingIEA ISSmolecular_function
GO:0043005Neuron projectionISScellular_component
GO:0043025Neuronal cell bodyISScellular_component
GO:0043197Dendritic spineIEA ISScellular_component
GO:0045211Postsynaptic membraneIEA ISScellular_component
GO:0060170Ciliary membraneISScellular_component
GO:0060291Long-term synaptic potentiationISSbiological_process
GO:0060292Long term synaptic depressionISSbiological_process
GO:0071625Vocalization behaviorIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34721148890.64202238520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0114597320
GSE13712_SHEARDown-0.0461576845
GSE13712_STATICDown-0.0138252342
GSE19018Down-0.0515187100
GSE19899_A1Down-0.0046963250
GSE19899_A2Down-0.3275305880
PubMed_21979375_A1Down-0.0919042867
PubMed_21979375_A2Down-0.0231825122
GSE35957Down-0.0007667865
GSE36640Up1.1158338667
GSE54402Down-0.0235651292
GSE9593Up0.5840172102
GSE43922Down-0.0852772666
GSE24585Up0.0096476783
GSE37065Down-0.2047493702
GSE28863_A1Down-0.1020186807
GSE28863_A2Up0.0726009645
GSE28863_A3Up0.3347195202
GSE28863_A4Up0.0991147789
GSE48662Up0.2054583689

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1307-3pMIMAT0005951MIRT035822CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.