HCSGD entry for SCAP
1. General information
| Official gene symbol | SCAP |
|---|---|
| Entrez ID | 22937 |
| Gene full name | SREBF chaperone |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | NAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | NAS | cellular_component |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0012507 | ER to Golgi transport vesicle membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0032933 | SREBP signaling pathway | IMP | biological_process |
| GO:0042304 | Regulation of fatty acid biosynthetic process | IEA | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045540 | Regulation of cholesterol biosynthetic process | IEA | biological_process |
| GO:0045541 | Negative regulation of cholesterol biosynthetic process | NAS | biological_process |
| GO:0045716 | Positive regulation of low-density lipoprotein particle receptor biosynthetic process | NAS | biological_process |
| GO:0051082 | Unfolded protein binding | NAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5907616124 | 0.2021827324 | 0.9999902473 | 0.8701196370 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0892664184 |
| GSE13712_SHEAR | Down | -0.2149719345 |
| GSE13712_STATIC | Down | -0.0816612703 |
| GSE19018 | Down | -0.1243362268 |
| GSE19899_A1 | Down | -0.3844206851 |
| GSE19899_A2 | Down | -0.4198981722 |
| PubMed_21979375_A1 | Up | 1.1556544509 |
| PubMed_21979375_A2 | Up | 0.8530843246 |
| GSE35957 | Down | -0.3726811771 |
| GSE36640 | Up | 0.3284835186 |
| GSE54402 | Down | -0.1209374222 |
| GSE9593 | Down | -0.2156840046 |
| GSE43922 | Up | 0.0085064525 |
| GSE24585 | Down | -0.0413043288 |
| GSE37065 | Down | -0.2866966122 |
| GSE28863_A1 | Up | 0.2201208664 |
| GSE28863_A2 | Up | 0.2142662888 |
| GSE28863_A3 | Down | -0.0843491992 |
| GSE28863_A4 | Down | -0.2793468683 |
| GSE48662 | Up | 0.0140579029 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-3p | MIMAT0004509 | MIRT038810 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047270 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047561 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
