HCSGD entry for CARD8
1. General information
| Official gene symbol | CARD8 |
|---|---|
| Entrez ID | 22900 |
| Gene full name | caspase recruitment domain family, member 8 |
| Other gene symbols | CARDINAL DACAR DAKAR NDPP NDPP1 TUCAN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | molecular_function |
| GO:0030163 | Protein catabolic process | IEA | biological_process |
| GO:0032089 | NACHT domain binding | IPI | molecular_function |
| GO:0032610 | Interleukin-1 alpha production | IEA | biological_process |
| GO:0032611 | Interleukin-1 beta production | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0050718 | Positive regulation of interleukin-1 beta secretion | IDA | biological_process |
| GO:0070269 | Pyroptosis | IEA | biological_process |
| GO:0072559 | NLRP3 inflammasome complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4361414346 | 0.5934479579 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0534595519 |
| GSE13712_SHEAR | Up | 0.4145427027 |
| GSE13712_STATIC | Up | 0.3475820251 |
| GSE19018 | Down | -0.0045464089 |
| GSE19899_A1 | Up | 0.0719224375 |
| GSE19899_A2 | Down | -0.3133032462 |
| PubMed_21979375_A1 | Up | 0.2330979894 |
| PubMed_21979375_A2 | Down | -0.4039796109 |
| GSE35957 | Down | -0.3647617447 |
| GSE36640 | Down | -0.1985493581 |
| GSE54402 | Up | 0.3544573523 |
| GSE9593 | Down | -0.0320844768 |
| GSE43922 | Up | 0.1859865593 |
| GSE24585 | Down | -0.0405506100 |
| GSE37065 | Down | -0.0401420170 |
| GSE28863_A1 | Up | 0.1091727607 |
| GSE28863_A2 | Down | -0.0761508918 |
| GSE28863_A3 | Down | -0.2093376810 |
| GSE28863_A4 | Up | 0.0053914315 |
| GSE48662 | Up | 0.1082494464 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000824 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000825 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-375 | MIMAT0000728 | MIRT019890 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
