HCSGD entry for IKZF3

1. General information

Official gene symbolIKZF3
Entrez ID22806
Gene full nameIKAROS family zinc finger 3 (Aiolos)
Other gene symbolsAIO AIOLOS ZNFN1A3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007498Mesoderm developmentTASbiological_process
GO:0030888Regulation of B cell proliferationIEA ISSbiological_process
GO:0042113B cell activationIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042981Regulation of apoptotic processIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEA ISSmolecular_function
GO:0045577Regulation of B cell differentiationIEA ISSbiological_process
GO:0045619Regulation of lymphocyte differentiationISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIDA IEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.77276166180.17664309110.99999024730.8133223194

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0057352283
GSE13712_SHEARUp0.0485457116
GSE13712_STATICDown-0.0193871372
GSE19018Up0.2118616585
GSE19899_A1Up0.0687143721
GSE19899_A2Down-0.0222535326
PubMed_21979375_A1Up0.0881499186
PubMed_21979375_A2Up0.0003200631
GSE35957Up0.1362777803
GSE36640Up0.1847639224
GSE54402Down-0.0212601193
GSE9593Down-0.0353741390
GSE43922Up0.0153157958
GSE24585Down-1.2280207728
GSE37065Down-0.0632842014
GSE28863_A1Down-0.4115918773
GSE28863_A2Down-0.4696288792
GSE28863_A3Up0.4534898534
GSE28863_A4Down-0.0561556021
GSE48662Up0.0520759201

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.