HCSGD entry for FGFR2

1. General information

Official gene symbolFGFR2
Entrez ID2263
Gene full namefibroblast growth factor receptor 2
Other gene symbolsBBDS BEK BFR-1 CD332 CEK3 CFD1 ECT1 JWS K-SAM KGFR TK14 TK25
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001525AngiogenesisISSbiological_process
GO:0001657Ureteric bud developmentISSbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001837Epithelial to mesenchymal transitionIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0003148Outflow tract septum morphogenesisISSbiological_process
GO:0003149Membranous septum morphogenesisISSbiological_process
GO:0004713Protein tyrosine kinase activityNASmolecular_function
GO:0005007Fibroblast growth factor-activated receptor activityIDA IEA IGI NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingISSbiological_process
GO:0007409AxonogenesisISSbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA IEA IGI IMPbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIDA IGI IPI TASbiological_process
GO:0008589Regulation of smoothened signaling pathwayISSbiological_process
GO:0009791Post-embryonic developmentISSbiological_process
GO:0009880Embryonic pattern specificationISSbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010453Regulation of cell fate commitmentISSbiological_process
GO:0010518Positive regulation of phospholipase activityIMPbiological_process
GO:0016020MembraneNAScellular_component
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016331Morphogenesis of embryonic epitheliumISSbiological_process
GO:0017134Fibroblast growth factor bindingIDA IPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0021769Orbitofrontal cortex developmentISSbiological_process
GO:0021847Ventricular zone neuroblast divisionISSbiological_process
GO:0021860Pyramidal neuron developmentISSbiological_process
GO:0022612Gland morphogenesisISSbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayISSbiological_process
GO:0030282Bone mineralizationISSbiological_process
GO:0030324Lung developmentISSbiological_process
GO:0030855Epithelial cell differentiationISSbiological_process
GO:0030901Midbrain developmentISSbiological_process
GO:0030916Otic vesicle formationISSbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031069Hair follicle morphogenesisISSbiological_process
GO:0032808Lacrimal gland developmentISSbiological_process
GO:0033688Regulation of osteoblast proliferationTASbiological_process
GO:0035264Multicellular organism growthISSbiological_process
GO:0035265Organ growthISSbiological_process
GO:0035602Fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrowISSbiological_process
GO:0035603Fibroblast growth factor receptor signaling pathway involved in hemopoiesisISSbiological_process
GO:0035604Fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrowISSbiological_process
GO:0035607Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0040014Regulation of multicellular organism growthISSbiological_process
GO:0040036Regulation of fibroblast growth factor receptor signaling pathwayISSbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0042476OdontogenesisISSbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045165Cell fate commitmentISSbiological_process
GO:0045667Regulation of osteoblast differentiationTASbiological_process
GO:0045787Positive regulation of cell cycleISSbiological_process
GO:0045839Negative regulation of mitosisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048333Mesodermal cell differentiationIEAbiological_process
GO:0048489Synaptic vesicle transportIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisISSbiological_process
GO:0048562Embryonic organ morphogenesisISSbiological_process
GO:0048565Digestive tract developmentISSbiological_process
GO:0048568Embryonic organ developmentISSbiological_process
GO:0048608Reproductive structure developmentISSbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEA IMPbiological_process
GO:0048705Skeletal system morphogenesisTASbiological_process
GO:0048730Epidermis morphogenesisISSbiological_process
GO:0048755Branching morphogenesis of a nerveISSbiological_process
GO:0048762Mesenchymal cell differentiationISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0051150Regulation of smooth muscle cell differentiationISSbiological_process
GO:0051781Positive regulation of cell divisionISSbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationISSbiological_process
GO:0060076Excitatory synapseISScellular_component
GO:0060174Limb bud formationISSbiological_process
GO:0060348Bone developmentISSbiological_process
GO:0060349Bone morphogenesisISSbiological_process
GO:0060365Coronal suture morphogenesisIEAbiological_process
GO:0060442Branching involved in prostate gland morphogenesisISSbiological_process
GO:0060445Branching involved in salivary gland morphogenesisISSbiological_process
GO:0060449Bud elongation involved in lung branchingISSbiological_process
GO:0060463Lung lobe morphogenesisISSbiological_process
GO:0060484Lung-associated mesenchyme developmentISSbiological_process
GO:0060501Positive regulation of epithelial cell proliferation involved in lung morphogenesisISSbiological_process
GO:0060512Prostate gland morphogenesisISSbiological_process
GO:0060523Prostate epithelial cord elongationISSbiological_process
GO:0060527Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisISSbiological_process
GO:0060529Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentISSbiological_process
GO:0060595Fibroblast growth factor receptor signaling pathway involved in mammary gland specificationISSbiological_process
GO:0060601Lateral sprouting from an epitheliumISSbiological_process
GO:0060615Mammary gland bud formationISSbiological_process
GO:0060664Epithelial cell proliferation involved in salivary gland morphogenesisISSbiological_process
GO:0060667Branch elongation involved in salivary gland morphogenesisISSbiological_process
GO:0060670Branching involved in labyrinthine layer morphogenesisISSbiological_process
GO:0060687Regulation of branching involved in prostate gland morphogenesisISSbiological_process
GO:0060688Regulation of morphogenesis of a branching structureISSbiological_process
GO:0060915Mesenchymal cell differentiation involved in lung developmentISSbiological_process
GO:0060916Mesenchymal cell proliferation involved in lung developmentISSbiological_process
GO:0061031Endodermal digestive tract morphogenesisIEAbiological_process
GO:0070307Lens fiber cell developmentIEAbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86872754830.34990183120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0447276636
GSE13712_SHEARUp0.0547703284
GSE13712_STATICDown-0.0609065202
GSE19018Up0.0747756781
GSE19899_A1Up0.0108865706
GSE19899_A2Up0.1254034439
PubMed_21979375_A1Up0.0387716129
PubMed_21979375_A2Down-0.0333510650
GSE35957Down-0.2420033314
GSE36640Up0.0531346236
GSE54402Down-0.0031186331
GSE9593Down-0.1890371828
GSE43922Up0.1439369658
GSE24585Down-0.1409418886
GSE37065Down-0.3962625405
GSE28863_A1Down-0.0260025401
GSE28863_A2Down-0.3723320968
GSE28863_A3Up0.2943040548
GSE28863_A4Up0.0256770275
GSE48662Down-0.0275819180

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1230020CHEMBL41429P21802
CHEMBL1241674CHEMBL41429P21802
CHEMBL1421CHEMBL41429P21802
CHEMBL259084CHEMBL41429P21802
CHEMBL191003CHEMBL41429P21802
CHEMBL1336CHEMBL41429P21802
CHEMBL1908397CHEMBL41429P21802
CHEMBL572878CHEMBL41429P21802
CHEMBL535CHEMBL41429P21802
CHEMBL572878CHEMBL41429P21802
CHEMBL1908395CHEMBL41429P21802
CHEMBL608533CHEMBL41429P21802
CHEMBL1421CHEMBL41429P21802
CHEMBL475251CHEMBL41429P21802
CHEMBL1933288CHEMBL41429P21802
CHEMBL24828CHEMBL41429P21802
CHEMBL522892CHEMBL41429P21802
CHEMBL1336CHEMBL41429P21802
CHEMBL477772CHEMBL41429P21802
CHEMBL1287853CHEMBL41429P21802
CHEMBL259084CHEMBL41429P21802
CHEMBL162CHEMBL41429P21802
CHEMBL608533CHEMBL41429P21802
CHEMBL509032CHEMBL41429P21802
CHEMBL522892CHEMBL41429P21802
CHEMBL1822792CHEMBL41429P21802
CHEMBL450786CHEMBL41429P21802
CHEMBL574738CHEMBL41429P21802
CHEMBL1908392CHEMBL41429P21802
CHEMBL1784637CHEMBL41429P21802
CHEMBL574738CHEMBL41429P21802
CHEMBL603469CHEMBL41429P21802
CHEMBL491473CHEMBL41429P21802
CHEMBL477772CHEMBL41429P21802
CHEMBL535CHEMBL41429P21802
CHEMBL1721885CHEMBL41429P21802
CHEMBL162CHEMBL41429P21802
CHEMBL1908393CHEMBL41429P21802
CHEMBL1721885CHEMBL41429P21802
CHEMBL24828CHEMBL41429P21802
CHEMBL386051CHEMBL41429P21802
CHEMBL230686CHEMBL41429P21802
CHEMBL1289926CHEMBL41429P21802
CHEMBL377300CHEMBL41429P21802
CHEMBL502835CHEMBL41429P21802
CHEMBL553CHEMBL41429P21802
CHEMBL535CHEMBL41429P21802
CHEMBL24828CHEMBL41429P21802
CHEMBL162CHEMBL41429P21802
CHEMBL571040CHEMBL41428P21802
CHEMBL569880CHEMBL41428P21802
CHEMBL603469CHEMBL41428P21802
CHEMBL171509CHEMBL41428P21802
CHEMBL355436CHEMBL41428P21802
CHEMBL495727CHEMBL41428P21802
CHEMBL414643CHEMBL41428P21802
CHEMBL352534CHEMBL41428P21802
CHEMBL598797CHEMBL41428P21802
CHEMBL168335CHEMBL41428P21802
CHEMBL354898CHEMBL41428P21802
CHEMBL169397CHEMBL41428P21802
CHEMBL172746CHEMBL41428P21802
CHEMBL535CHEMBL41428P21802
CHEMBL170415CHEMBL41428P21802
CHEMBL276125CHEMBL41428P21802
CHEMBL352342CHEMBL41428P21802
CHEMBL354830CHEMBL41428P21802
CHEMBL1336CHEMBL41428P21802
CHEMBL535CHEMBL41428P21802
CHEMBL354902CHEMBL41428P21802
CHEMBL170907CHEMBL41428P21802
CHEMBL162CHEMBL41428P21802
CHEMBL169854CHEMBL41428P21802
CHEMBL608533CHEMBL41428P21802
CHEMBL352308CHEMBL41428P21802
CHEMBL169837CHEMBL41428P21802
CHEMBL171413CHEMBL41428P21802
CHEMBL167425CHEMBL41428P21802
CHEMBL1834657CHEMBL41428P21802
CHEMBL1834657CHEMBL41428P21802
CHEMBL453737CHEMBL41428P21802
CHEMBL354224CHEMBL41428P21802
CHEMBL429743CHEMBL41428P21802
CHEMBL170519CHEMBL41428P21802
CHEMBL1779202CHEMBL41428P21802
CHEMBL1172957CHEMBL41428P21802
CHEMBL162CHEMBL41428P21802
CHEMBL1779202CHEMBL41428P21802
CHEMBL600795CHEMBL41428P21802
CHEMBL1834657CHEMBL41428P21802
CHEMBL602472CHEMBL41428P21802
CHEMBL103667CHEMBL41428P21802
CHEMBL602471CHEMBL41428P21802
CHEMBL21156CHEMBL41428P21802
CHEMBL177688CHEMBL41427P21802
CHEMBL178455CHEMBL41426P21802
CHEMBL363130CHEMBL41426P21802
CHEMBL190984CHEMBL41426P21802
CHEMBL363607CHEMBL41426P21802
CHEMBL372657CHEMBL41426P21802
CHEMBL191003CHEMBL41426P21802
CHEMBL177688CHEMBL41426P21802
CHEMBL371169CHEMBL41426P21802
CHEMBL188386CHEMBL41426P21802
CHEMBL606964CHEMBL41425P21802
CHEMBL212084CHEMBL41425P21802
CHEMBL196363CHEMBL41425P21802
CHEMBL381207CHEMBL41425P21802
CHEMBL142648CHEMBL41425P21802
CHEMBL143491CHEMBL41425P21802
CHEMBL140808CHEMBL41425P21802
CHEMBL143147CHEMBL41425P21802
CHEMBL231568CHEMBL41425P21802
CHEMBL139653CHEMBL41425P21802
CHEMBL140373CHEMBL41425P21802
CHEMBL356603CHEMBL41425P21802
CHEMBL223360CHEMBL41424P21802
CHEMBL370808CHEMBL41424P21802
CHEMBL51283CHEMBL41424P21802
CHEMBL298679CHEMBL41424P21802
CHEMBL301483CHEMBL41424P21802
CHEMBL297523CHEMBL41424P21802
CHEMBL50647CHEMBL41424P21802
CHEMBL299763CHEMBL41424P21802
CHEMBL99049CHEMBL41424P21802
CHEMBL99352CHEMBL41424P21802
CHEMBL98396CHEMBL41424P21802
CHEMBL317768CHEMBL41424P21802
CHEMBL50470CHEMBL41424P21802
CHEMBL299763CHEMBL41424P21802
CHEMBL57347CHEMBL41424P21802
CHEMBL49120CHEMBL41424P21802
CHEMBL56236CHEMBL41424P21802
CHEMBL299026CHEMBL41424P21802
CHEMBL48809CHEMBL41424P21802
CHEMBL299763CHEMBL41424P21802
CHEMBL49596CHEMBL41424P21802
CHEMBL57366CHEMBL41424P21802
CHEMBL57323CHEMBL41424P21802
CHEMBL45827CHEMBL41424P21802
CHEMBL217863CHEMBL41424P21802
CHEMBL75188CHEMBL41424P21802
CHEMBL190281CHEMBL41424P21802
CHEMBL76599CHEMBL41424P21802
CHEMBL57366CHEMBL41424P21802
CHEMBL201307CHEMBL41424P21802
CHEMBL45827CHEMBL41424P21802
CHEMBL316567CHEMBL41424P21802
CHEMBL101457CHEMBL41424P21802
CHEMBL99724CHEMBL41424P21802
CHEMBL425876CHEMBL41424P21802
CHEMBL99077CHEMBL41424P21802
CHEMBL301612CHEMBL41424P21802
CHEMBL365847CHEMBL41424P21802
CHEMBL51485CHEMBL41424P21802
CHEMBL296540CHEMBL41424P21802
CHEMBL329706CHEMBL41424P21802
CHEMBL432314CHEMBL41424P21802
CHEMBL316508CHEMBL41424P21802
CHEMBL162CHEMBL41424P21802
CHEMBL299194CHEMBL41424P21802
CHEMBL432738CHEMBL41424P21802
CHEMBL49120CHEMBL41424P21802
CHEMBL51028CHEMBL41424P21802
CHEMBL98447CHEMBL41424P21802
CHEMBL48172CHEMBL41424P21802
CHEMBL21156CHEMBL41424P21802
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  • Drugs

Name

Drug

Accession number

PaliferminDB00039 BTD00042 | BIOD00042
SU4984DB02058 EXPT02973
4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-AmineDB02491 EXPT00378
RegorafenibDB08896 -
PonatinibDB08901 -
LenvatinibDB09078 -
NintedanibDB09079 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-19b-1-5pMIMAT0004491MIRT006275Luciferase reporter assay//Western blotFunctional MTI22197821
hsa-miR-125b-5pMIMAT0000423MIRT006678Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21412257
hsa-miR-1MIMAT0000416MIRT023494MicroarrayFunctional MTI (Weak)18668037
hsa-miR-186-5pMIMAT0000456MIRT044917CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24448819Mutations in fibroblast growth factor receptor 2 (FGFR2) have been recently described as a molecular-specific feature in endometrial carcinomas and the presence of activated FGFR2 mutations is associated with poor prognosis
24448819For that reason, inhibition of FGFR2 could be a therapeutic target in the treatment of endometriod carcinomas
24448819Because blocking one signaling pathway is often not sufficient to cause total tumor regression and the effectiveness of individual inhibitors is often short-lived, we examined the impact of targeting FGFR2 with dovitinib in combination with a selective ER antagonist, fulvestrant (ICI182
24448819780 treatment can be truly effective in patients with endometrial carcinomas carrying FGFR2 mutations
23174937Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2
20032303PEA-15 binding prevented ERK1/2 membrane recruitment and threonine phosphorylation of fibroblast receptor substrate 2alpha (FRS2alpha), a key link in fibroblast growth factor (FGF) receptor activation of ERK1/2
8972724FGF receptor (R)-1 substrates were not tyrosine phosphorylated in either young or senescent IMR-90 cells
8707855We report that in both presenescent and senescent HUVEC populations, FGF-1 induces the expression of cell cycle-specific genes, suggesting that functional FGF receptor (FGFR) may exist on the surface of these cells
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