HCSGD entry for FGFR3

1. General information

Official gene symbolFGFR3
Entrez ID2261
Gene full namefibroblast growth factor receptor 3
Other gene symbolsACH CD333 CEK2 HSFGFR3EX JTK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0001501Skeletal system developmentIEA TASbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0001958Endochondral ossificationTASbiological_process
GO:0002009Morphogenesis of an epitheliumIEAbiological_process
GO:0002062Chondrocyte differentiationTASbiological_process
GO:0002089Lens morphogenesis in camera-type eyeIEAbiological_process
GO:0003416Endochondral bone growthTASbiological_process
GO:0004713Protein tyrosine kinase activityIDAmolecular_function
GO:0005007Fibroblast growth factor-activated receptor activityIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005925Focal adhesionTAScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0007267Cell-cell signalingIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEA IGI IMPbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIDA IGI TASbiological_process
GO:0009898Cytoplasmic side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIEAcellular_component
GO:0010518Positive regulation of phospholipase activityIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0017134Fibroblast growth factor bindingIDA IPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0021762Substantia nigra developmentIEAbiological_process
GO:0022010Central nervous system myelinationIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035988Chondrocyte proliferationTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIMPbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIMPbiological_process
GO:0043410Positive regulation of MAPK cascadeIMPbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIMP TASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0045839Negative regulation of mitosisIEAbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayIEAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0048546Digestive tract morphogenesisIEAbiological_process
GO:0048640Negative regulation of developmental growthISSbiological_process
GO:0048678Response to axon injuryIEAbiological_process
GO:0048712Negative regulation of astrocyte differentiationIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0060113Inner ear receptor cell differentiationIEAbiological_process
GO:0060349Bone morphogenesisTASbiological_process
GO:0060385Axonogenesis involved in innervationIEAbiological_process
GO:0061144Alveolar secondary septum developmentIEAbiological_process
GO:0070307Lens fiber cell developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070977Bone maturationISSbiological_process
GO:0072148Epithelial cell fate commitmentIEAbiological_process
GO:0090080Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0090102Cochlea developmentIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:1902178Fibroblast growth factor receptor apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82837844690.15441602520.99999024730.7593955726

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1818561321
GSE13712_SHEARDown-1.1070059215
GSE13712_STATICUp0.0999070530
GSE19018Down-0.5484459144
GSE19899_A1Up0.0175992959
GSE19899_A2Down-0.6406574030
PubMed_21979375_A1Up0.1681136039
PubMed_21979375_A2Down-0.1963992024
GSE35957Up0.0661444568
GSE36640Up0.0256190015
GSE54402Down-0.1137261727
GSE9593Down-0.3974878964
GSE43922Up0.0458586752
GSE24585Up0.0130416857
GSE37065Down-0.0517493479
GSE28863_A1Down-0.1360187952
GSE28863_A2Up0.0531256858
GSE28863_A3Up0.4273670056
GSE28863_A4Down-0.0171756717
GSE48662Up0.1025288785

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliferminDB00039 BTD00042 | BIOD00042
XL999DB05014 -
PazopanibDB06589 -
PonatinibDB08901 -
LenvatinibDB09078 -
NintedanibDB09079 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-100-5pMIMAT0000098MIRT003419Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19843843
hsa-miR-100-5pMIMAT0000098MIRT003419Microarray//qRT-PCR//Western blotFunctional MTI19396866
hsa-miR-99a-5pMIMAT0000097MIRT004243Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19843843
hsa-miR-99a-5pMIMAT0000097MIRT004243Reporter assay;Western blotFunctional MTI21383697
hsa-miR-26b-5pMIMAT0000083MIRT030099MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-99a-5pMIMAT0000097NAhsa-miR-99a{Western blot}{downregulation by anti-miRNA oligonucleotide}19843843
hsa-miR-100-5pMIMAT0000098NAhsa-miR-100{Western blot}{downregulation by anti-miRNA oligonucleotide}19843843
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26142204Vasodilator responses to acetylcholine (Ach) in the isolated aortic rings were measured, serum concentration of glucose, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) and the expression of VPO1 in the aorta were determined
26142204RESULTS: Vasodilator responses to Ach were impaired markedly and the serum concentrations of glucose, TNF-alpha and MCP-1 were significantly increased in diabetic rats
20362703FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence
20362703In FGFR3-related skeletal dyplasias, oncogenic mutations in the FGFR3 receptor tyrosine kinase cause profound inhibition of cartilage growth resulting in severe dwarfism, although many of the precise mechanisms of FGFR3 action remain unclear
20362703Mutated FGFR3 induces constitutive activation of the ERK pathway in chondrocytes and, remarkably, can also cause both increased proliferation and apoptosis in growing cartilage, depending on the gestational age
20362703Here, we demonstrate that FGFR3 signaling is also capable of inducing premature senescence in chondrocytes, manifested as reversible, ERK-dependent growth arrest accompanied by alteration of cellular shape, loss of the extracellular matrix, upregulation of senescence markers (alpha-GLUCOSIDASE, FIBRONECTIN, CAVEOLIN 1, LAMIN A, SM22alpha and TIMP 1), and induction of senescence-associated beta-GALACTOSIDASE activity
20362703Our data support a model whereby FGFR3 signaling inhibits cartilage growth via exploiting cellular responses originally designed to eliminate cells harboring activated oncogenes
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