HCSGD entry for FGF7

1. General information

Official gene symbolFGF7
Entrez ID2252
Gene full namefibroblast growth factor 7
Other gene symbolsHBGF-7 KGF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005104Fibroblast growth factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEA IGIbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIEA IGI TASbiological_process
GO:0008544Epidermis developmentTASbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0010463Mesenchymal cell proliferationIDAbiological_process
GO:0010838Positive regulation of keratinocyte proliferationIDAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031532Actin cytoskeleton reorganizationIDAbiological_process
GO:0034394Protein localization to cell surfaceIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051549Positive regulation of keratinocyte migrationIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0060501Positive regulation of epithelial cell proliferation involved in lung morphogenesisIDAbiological_process
GO:0060665Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingIEAbiological_process
GO:0061033Secretion by lung epithelial cell involved in lung growthIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68433401470.01236024470.99999024730.2194385705

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0328401277
GSE13712_SHEARDown-0.0475417814
GSE13712_STATICDown-0.0268841303
GSE19018Down-0.2884097914
GSE19899_A1Down-0.4644238834
GSE19899_A2Down-0.7773465517
PubMed_21979375_A1Down-1.0250173627
PubMed_21979375_A2Down-1.3062691068
GSE35957Up0.7109907192
GSE36640Up0.8292740176
GSE54402Down-1.5470944624
GSE9593Down-0.6600269637
GSE43922Down-0.9503562934
GSE24585Up0.3285012062
GSE37065Down-0.0933105501
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.4565504228

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT003482Luciferase reporter assayFunctional MTI19701459
hsa-miR-155-5pMIMAT0000646MIRT003482Luciferase reporter assayFunctional MTI19177201
hsa-miR-155-5pMIMAT0000646MIRT003482ProteomicsFunctional MTI (Weak)18668040
hsa-miR-20a-5pMIMAT0000075MIRT050488CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT00006461hsa-miR-155{ELISA}{overexpression by miRNA precursor transfection}19701459
hsa-miR-155-5pMIMAT00006462hsa-miR-155{ELISA}{overexpression by miRNA precursor transfection}19701459
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20038483IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis
16424011The paracrine-acting proteins fibroblast growth factor 7, hepatocyte growth factor, and amphiregulin (AREG) were elevated in the extracellular environment of senescent prostate fibroblasts
12640658In BPH, there is an increased expression of Il-1alpha by prostatic epithelial cells that results in elevated expression of FGF7 by stromal cells, which in turn is strongly correlated with epithelial proliferation
12640658CONCLUSIONS: One mechanism driving BPH in older men is the accumulation of senescent epithelial cells expressing Il-1alpha, which in turn increases FGF7 secretion and proliferation of non-senescent epithelial cells
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