HCSGD entry for FEN1

1. General information

Official gene symbolFEN1
Entrez ID2237
Gene full nameflap structure-specific endonuclease 1
Other gene symbolsFEN-1 MF1 RAD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0000722Telomere maintenance via recombinationTASbiological_process
GO:0000723Telomere maintenanceTASbiological_process
GO:0000737DNA catabolic process, endonucleolyticIDA IMPbiological_process
GO:0000738DNA catabolic process, exonucleolyticTASbiological_process
GO:0003677DNA bindingIEA IMPmolecular_function
GO:0003684Damaged DNA bindingTASmolecular_function
GO:0003690Double-stranded DNA bindingTASmolecular_function
GO:0004518Nuclease activityIEAmolecular_function
GO:0004519Endonuclease activityTASmolecular_function
GO:0004523RNA-DNA hybrid ribonuclease activityIDAmolecular_function
GO:0004527Exonuclease activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0006260DNA replicationIEA NASbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0006281DNA repairIEA NAS TASbiological_process
GO:0006284Base-excision repairTASbiological_process
GO:0006302Double-strand break repairTASbiological_process
GO:0006308DNA catabolic processIDA IMP TASbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008309Double-stranded DNA exodeoxyribonuclease activityTASmolecular_function
GO:00084095'-3' exonuclease activityIDAmolecular_function
GO:0009650UV protectionTASbiological_process
GO:00171085'-flap endonuclease activityIDA IMPmolecular_function
GO:0030145Manganese ion bindingIEAmolecular_function
GO:0032201Telomere maintenance via semi-conservative replicationTASbiological_process
GO:0043137DNA replication, removal of RNA primerIDAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0048256Flap endonuclease activityIEAmolecular_function
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDA IMP TASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisIDAbiological_process
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96943405650.00048757650.99999024730.0411066038

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2145476134
GSE13712_SHEARUp0.3026353570
GSE13712_STATICUp0.1255637657
GSE19018Down-0.5073234880
GSE19899_A1Down-0.7616931544
GSE19899_A2Down-1.9018960602
PubMed_21979375_A1Down-1.6832687004
PubMed_21979375_A2Down-2.5172236438
GSE35957Down-2.4427548003
GSE36640Down-2.5390118835
GSE54402Up0.1065117927
GSE9593Down-1.0140189322
GSE43922Down-0.2299259195
GSE24585Up0.1269637310
GSE37065Down-0.0704373316
GSE28863_A1Down-0.5000390497
GSE28863_A2Down-0.2047077115
GSE28863_A3Up0.3059850565
GSE28863_A4Down-0.2521354716
GSE48662Down-1.0816446912

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT000116Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Microarray;OtherFunctional MTI19748357
hsa-miR-193b-3pMIMAT0002819MIRT016610ProteomicsFunctional MTI (Weak)21512034
hsa-miR-193b-3pMIMAT0002819MIRT016610MicroarrayFunctional MTI (Weak)20304954
hsa-miR-215-5pMIMAT0000272MIRT024421MicroarrayFunctional MTI (Weak)19074876
hsa-miR-34a-5pMIMAT0000255MIRT025481ProteomicsFunctional MTI (Weak)21566225
hsa-miR-192-5pMIMAT0000222MIRT026838MicroarrayFunctional MTI (Weak)19074876
hsa-miR-1229-3pMIMAT0005584MIRT036309CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042974CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047080CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052079CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-24-3pMIMAT00000801hsa-miR-2419748357
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19699691Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity
19699691It has been established that during nuclear long-patch (LP) BER, FEN1 is responsible for cleavage of 5' flap structures generated during DNA synthesis
19699691Furthermore, removal of 5' flaps has been observed in mitochondrial extracts of mammalian cell lines; yet, the mitochondrial localization of FEN1 has not been clearly demonstrated
19699691In this study, we analyzed the effects of deleting the yeast FEN1 homolog, RAD27, on mtDNA stability in Saccharomyces cerevisiae
19699691Our findings demonstrate that Rad27p/FEN1 is localized in the mitochondrial compartment of both yeast and mice and that Rad27p has a significant role in maintaining mtDNA integrity
7908266Normal human embryonic lung fibroblasts WI-38 differentiate spontaneously along the cell lineage mitotic fibroblasts (MF) I, II, and III and postmitotic fibroblasts (PMF) IV, V, VI, and VII in the fibroblast stem cell system in vitro, when appropriate methods are applied
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