HCSGD entry for ALDH9A1
1. General information
| Official gene symbol | ALDH9A1 |
|---|---|
| Entrez ID | 223 |
| Gene full name | aldehyde dehydrogenase 9 family, member A1 |
| Other gene symbols | ALDH4 ALDH7 ALDH9 E3 TMABADH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity | TAS | molecular_function |
| GO:0004029 | Aldehyde dehydrogenase (NAD) activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006081 | Cellular aldehyde metabolic process | IDA | biological_process |
| GO:0009437 | Carnitine metabolic process | IEA | biological_process |
| GO:0019145 | Aminobutyraldehyde dehydrogenase activity | IDA IEA | molecular_function |
| GO:0033737 | 1-pyrroline dehydrogenase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042136 | Neurotransmitter biosynthetic process | IDA | biological_process |
| GO:0042445 | Hormone metabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0043176 | Amine binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045329 | Carnitine biosynthetic process | IEA TAS | biological_process |
| GO:0047105 | 4-trimethylammoniobutyraldehyde dehydrogenase activity | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1253712967 | 0.5387036815 | 0.7225497592 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3681715677 |
| GSE13712_SHEAR | Down | -0.2230217086 |
| GSE13712_STATIC | Down | -0.0790557526 |
| GSE19018 | Up | 0.2365077324 |
| GSE19899_A1 | Up | 0.4948555697 |
| GSE19899_A2 | Up | 0.3773802952 |
| PubMed_21979375_A1 | Down | -0.1444807673 |
| PubMed_21979375_A2 | Up | 0.5067179131 |
| GSE35957 | Down | -0.0520196505 |
| GSE36640 | Up | 0.0115750379 |
| GSE54402 | Down | -0.1544743180 |
| GSE9593 | Up | 0.1627784128 |
| GSE43922 | Down | -0.0345381437 |
| GSE24585 | Up | 0.4791899432 |
| GSE37065 | Down | -0.2638454294 |
| GSE28863_A1 | Up | 0.5541854044 |
| GSE28863_A2 | Up | 0.1830307855 |
| GSE28863_A3 | Down | -0.7546696218 |
| GSE28863_A4 | Down | -0.1240349468 |
| GSE48662 | Down | -0.1737990451 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002631 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002631 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020624 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024328 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025249 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026254 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028704 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-497-5p | MIMAT0002820 | MIRT041186 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045873 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048479 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049809 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
