HCSGD entry for FDPS
1. General information
| Official gene symbol | FDPS |
|---|---|
| Entrez ID | 2224 |
| Gene full name | farnesyl diphosphate synthase |
| Other gene symbols | FPPS FPS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004161 | Dimethylallyltranstransferase activity | IEA | molecular_function |
| GO:0004337 | Geranyltranstransferase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0033384 | Geranyl diphosphate biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045337 | Farnesyl diphosphate biosynthetic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0172520003 | 0.9329692071 | 0.3231956584 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2146718415 |
| GSE13712_SHEAR | Down | -0.1294260947 |
| GSE13712_STATIC | Down | -0.4115436780 |
| GSE19018 | Up | 0.1548189975 |
| GSE19899_A1 | Up | 1.1066682758 |
| GSE19899_A2 | Up | 0.9765259074 |
| PubMed_21979375_A1 | Up | 0.0670641456 |
| PubMed_21979375_A2 | Up | 0.4734418516 |
| GSE35957 | Down | -0.2819851574 |
| GSE36640 | Up | 0.6019649339 |
| GSE54402 | Up | 0.3925862747 |
| GSE9593 | Up | 0.0717460863 |
| GSE43922 | Up | 0.5578847225 |
| GSE24585 | Down | -0.2174609105 |
| GSE37065 | Up | 0.0678184838 |
| GSE28863_A1 | Up | 0.0734110317 |
| GSE28863_A2 | Up | 0.2163655253 |
| GSE28863_A3 | Down | -0.1613194028 |
| GSE28863_A4 | Up | 0.0435865836 |
| GSE48662 | Up | 0.0499320509 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pamidronate | DB00282 | APRD01161 |
| Zoledronic acid | DB00399 | APRD01294 | DB06286 |
| Alendronic acid | DB00630 | APRD00561 |
| Ibandronate | DB00710 | APRD00231 | DB04635 |
| Risedronate | DB00884 | APRD00410 | DB02782 |
| Dimethylallyl Diphosphate | DB01785 | EXPT01221 |
| Isopentyl Pyrophosphate | DB02508 | EXPT01922 |
| Geranyl Diphosphate | DB02552 | EXPT01640 |
| ISOPENTENYL PYROPHOSPHATE | DB04714 | - |
| FARNESYL DIPHOSPHATE | DB07780 | - |
| GERANYLGERANYL DIPHOSPHATE | DB07841 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30c-2-3p | MIMAT0004550 | MIRT038702 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051567 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19345325 | Here, we demonstrate that pRb inactivation induces aberrant expression of farnesyl diphosphate synthase, many prenyltransferases, and their upstream regulators sterol regulatory element-binding proteins (SREBPs) in an E2F-dependent manner, leading to enhanced isoprenylation and activation of N-Ras |
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