HCSGD entry for FDFT1
1. General information
| Official gene symbol | FDFT1 |
|---|---|
| Entrez ID | 2222 |
| Gene full name | farnesyl-diphosphate farnesyltransferase 1 |
| Other gene symbols | DGPT ERG9 SQS SS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004310 | Farnesyl-diphosphate farnesyltransferase activity | IEA TAS | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006694 | Steroid biosynthetic process | TAS | biological_process |
| GO:0006695 | Cholesterol biosynthetic process | TAS | biological_process |
| GO:0008299 | Isoprenoid biosynthetic process | IEA | biological_process |
| GO:0008610 | Lipid biosynthetic process | IEA | biological_process |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045338 | Farnesyl diphosphate metabolic process | IEA | biological_process |
| GO:0051996 | Squalene synthase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0940468295 | 0.0973649139 | 0.6428087701 | 0.5954325976 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9003888721 |
| GSE13712_SHEAR | Down | -0.3580350934 |
| GSE13712_STATIC | Down | -0.5451520979 |
| GSE19018 | Up | 0.0848304048 |
| GSE19899_A1 | Up | 0.7834946995 |
| GSE19899_A2 | Up | 0.9097572618 |
| PubMed_21979375_A1 | Down | -0.4498243254 |
| PubMed_21979375_A2 | Up | 0.5556613815 |
| GSE35957 | Down | -0.1873270938 |
| GSE36640 | Up | 0.6357771968 |
| GSE54402 | Up | 0.1571094070 |
| GSE9593 | Up | 0.0851091004 |
| GSE43922 | Up | 0.3279411586 |
| GSE24585 | Down | -0.3093315465 |
| GSE37065 | Up | 0.3019683678 |
| GSE28863_A1 | Down | -0.7975565848 |
| GSE28863_A2 | Down | -0.5637469587 |
| GSE28863_A3 | Down | -0.6862613300 |
| GSE28863_A4 | Down | -0.1062155610 |
| GSE48662 | Down | -0.1432906441 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| TAK-475 | DB05317 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018425 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020885 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029745 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-760 | MIMAT0004957 | MIRT036774 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045529 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
