HCSGD entry for FBN1
1. General information
| Official gene symbol | FBN1 |
|---|---|
| Entrez ID | 2200 |
| Gene full name | fibrillin 1 |
| Other gene symbols | ACMICD ECTOL1 FBN GPHYSD2 MASS MFS1 OCTD SGS SSKS WMS WMS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IMP | biological_process |
| GO:0001527 | Microfibril | IDA | cellular_component |
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | IDA IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IDA IEA | cellular_component |
| GO:0005604 | Basement membrane | IDA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0007507 | Heart development | IMP | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA IEA | cellular_component |
| GO:0035582 | Sequestering of BMP in extracellular matrix | ISS | biological_process |
| GO:0035583 | Sequestering of TGFbeta in extracellular matrix | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0679960678 | 0.0019329661 | 0.5605946445 | 0.0846848435 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.9652590045 |
| GSE13712_SHEAR | Down | -2.0697457298 |
| GSE13712_STATIC | Down | -1.2833613428 |
| GSE19018 | Down | -0.0892568184 |
| GSE19899_A1 | Down | -0.9330459799 |
| GSE19899_A2 | Down | -2.1832760254 |
| PubMed_21979375_A1 | Down | -2.2192610078 |
| PubMed_21979375_A2 | Down | -2.6310997474 |
| GSE35957 | Up | 0.2812885416 |
| GSE36640 | Up | 0.3534791517 |
| GSE54402 | Down | -0.6777052068 |
| GSE9593 | Up | 0.6195822460 |
| GSE43922 | Down | -0.3868552130 |
| GSE24585 | Up | 0.6941666708 |
| GSE37065 | Down | -0.2541105122 |
| GSE28863_A1 | Up | 1.6532334847 |
| GSE28863_A2 | Up | 1.6546872445 |
| GSE28863_A3 | Down | -0.1449232213 |
| GSE28863_A4 | Up | 0.3537317898 |
| GSE48662 | Up | 0.3877505640 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT003829 | Luciferase reporter assay//qRT-PCR | Functional MTI | 18390668 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT021695 | Microarray | Functional MTI (Weak) | 21396852 |
| hsa-miR-1 | MIMAT0000416 | MIRT023759 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024378 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026557 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028608 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046011 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26569300 | AQFE reduced CML expression and stimulated fibrillin-1 expression in comparison to the methyglyoxal treatment |
| 19176530 | Here we show that the assembly of stress granules (SGs) is part of the early events used by senescent cells to respond to certain stresses |
| 19176530 | Although SGs can form in response to stress during senescence activation, their number significantly increases once the cells are fully senescent |
| 19176530 | Throughout stress, p21 mRNA is stabilized and localizes to SGs, but only during late senescence does this localization interferes with its translation |
| 11542340 | The purpose of this work was: a) to study the behaviour of two rat cell strains (neoplastic SGS/4A and syngeneic fibroblasts FG) in order to test whether adhesion-dependent cells are suitable for clinorotation and b) to investigate cell-cell and cell-substratum adhesion in these cells kept under simulated low-g in the fast rotating clinostat and in hypergravity at l0g in the centrifuge |
| 10832101 | As the in vitro cellular system of the neoplastic cell line SGS/4A and syngeneic normal fibroblasts (FG) represents a useful tool for studies on molecular mechanisms regulating cell adhesion, neoplastic transformation and cellular ageing, we studied the changes of glycosphingolipid and of the enzymes involved in their metabolism in both cultured cells at different subculture stages |
| 10832101 | On the contrary, the increasing number of SGS/4A subcultures, characterized by a specific and different glycosphingolipid composition as compared with FG cells, does not cause modifications |
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