HCSGD entry for ALDH1A3

1. General information

Official gene symbolALDH1A3
Entrez ID220
Gene full namealdehyde dehydrogenase 1 family, member A3
Other gene symbolsALDH1A6 ALDH6 MCOP8 RALDH3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002072Optic cup morphogenesis involved in camera-type eye developmentIEAbiological_process
GO:0002138Retinoic acid biosynthetic processIEAbiological_process
GO:0004029Aldehyde dehydrogenase (NAD) activityIEAmolecular_function
GO:0004030Aldehyde dehydrogenase [NAD(P)+] activityIDAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0007626Locomotory behaviorIEAbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016620Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorIEAmolecular_function
GO:0021768Nucleus accumbens developmentIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042572Retinol metabolic processIEAbiological_process
GO:0042573Retinoic acid metabolic processIDAbiological_process
GO:0042574Retinal metabolic processIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0048048Embryonic eye morphogenesisISSbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0060013Righting reflexIEAbiological_process
GO:0060166Olfactory pit developmentIEAbiological_process
GO:0060324Face developmentIEAbiological_process
GO:0070324Thyroid hormone bindingIEAmolecular_function
GO:0070403NAD+ bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47180190340.03476850040.99999024730.3527386898

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2139157463
GSE13712_SHEARUp0.3510401915
GSE13712_STATICUp0.3612810843
GSE19018Down-0.2190927816
GSE19899_A1Down-0.0868746467
GSE19899_A2Down-0.3331154964
PubMed_21979375_A1Down-0.5664854283
PubMed_21979375_A2Down-0.7492658331
GSE35957Up0.3914148830
GSE36640Down-3.3345502374
GSE54402Down-0.9480069591
GSE9593Down-0.3592248349
GSE43922Down-0.0159372638
GSE24585Up0.0383313716
GSE37065Down-0.0309167555
GSE28863_A1Up0.1961014597
GSE28863_A2Up0.4952813409
GSE28863_A3Up0.2283709033
GSE28863_A4Up0.0938315010
GSE48662Down-0.6819116371

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Vitamin ADB00162 NUTR00007 | APRD00486

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT021438MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025948MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.