HCSGD entry for ACSL1
1. General information
| Official gene symbol | ACSL1 |
|---|---|
| Entrez ID | 2180 |
| Gene full name | acyl-CoA synthetase long-chain family member 1 |
| Other gene symbols | ACS1 FACL1 FACL2 LACS LACS1 LACS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001676 | Long-chain fatty acid metabolic process | IDA | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004467 | Long-chain fatty acid-CoA ligase activity | IDA IEA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IEA TAS | cellular_component |
| GO:0005778 | Peroxisomal membrane | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006641 | Triglyceride metabolic process | IEA | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0008610 | Lipid biosynthetic process | IDA | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0015908 | Fatty acid transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0033211 | Adiponectin-activated signaling pathway | IEA | biological_process |
| GO:0033559 | Unsaturated fatty acid metabolic process | TAS | biological_process |
| GO:0034201 | Response to oleic acid | IEA | biological_process |
| GO:0035338 | Long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0036109 | Alpha-linolenic acid metabolic process | TAS | biological_process |
| GO:0042178 | Xenobiotic catabolic process | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043651 | Linoleic acid metabolic process | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0044539 | Long-chain fatty acid import | IDA | biological_process |
| GO:0071902 | Positive regulation of protein serine/threonine kinase activity | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1054967326 | 0.2108912579 | 0.6746067525 | 0.8868141284 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3968858943 |
| GSE13712_SHEAR | Down | -0.1418369802 |
| GSE13712_STATIC | Up | 0.0731840302 |
| GSE19018 | Down | -0.4040529318 |
| GSE19899_A1 | Down | -0.1299691167 |
| GSE19899_A2 | Up | 0.1884428994 |
| PubMed_21979375_A1 | Up | 0.0428596176 |
| PubMed_21979375_A2 | Up | 0.5771953733 |
| GSE35957 | Up | 0.3281133632 |
| GSE36640 | Up | 1.0115808119 |
| GSE54402 | Up | 0.7234661866 |
| GSE9593 | Up | 0.5228058642 |
| GSE43922 | Down | -0.0088787313 |
| GSE24585 | Down | -0.2017883644 |
| GSE37065 | Up | 0.2414283196 |
| GSE28863_A1 | Down | -0.0953401222 |
| GSE28863_A2 | Up | 0.4243668869 |
| GSE28863_A3 | Down | -0.6200698737 |
| GSE28863_A4 | Down | -0.4121476244 |
| GSE48662 | Down | -0.5067097332 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017213 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025381 | Reporter assay;Proteomics//Proteomics | Functional MTI | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026287 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032285 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038888 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045814 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
