HCSGD entry for F12

1. General information

Official gene symbolF12
Entrez ID2161
Gene full namecoagulation factor XII (Hageman factor)
Other gene symbolsHAE3 HAEX HAF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002353Plasma kallikrein-kinin cascadeIDAbiological_process
GO:0002542Factor XII activationIDAbiological_process
GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayIC TASbiological_process
GO:0010756Positive regulation of plasminogen activationIDAbiological_process
GO:0016485Protein processingIDAbiological_process
GO:0016540Protein autoprocessingIDAbiological_process
GO:0030194Positive regulation of blood coagulationIDAbiological_process
GO:0031638Zymogen activationIDAbiological_process
GO:0042730FibrinolysisIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051787Misfolded protein bindingICmolecular_function
GO:0051788Response to misfolded proteinIDAbiological_process
GO:0051919Positive regulation of fibrinolysisIDAbiological_process
GO:0070009Serine-type aminopeptidase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21315649480.89834880890.88970696161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0828297639
GSE13712_SHEARDown-0.0423449751
GSE13712_STATICDown-0.0397598944
GSE19018Up0.1527262146
GSE19899_A1Up0.0760192472
GSE19899_A2Up0.1286903237
PubMed_21979375_A1Up0.2610607813
PubMed_21979375_A2Up0.4894888782
GSE35957Down-0.1838958662
GSE36640Down-0.1274755964
GSE54402Down-0.0248797356
GSE9593Down-0.0803785603
GSE43922Up0.1353962388
GSE24585Up0.2923162588
GSE37065Up0.0207599093
GSE28863_A1Down-0.0903121914
GSE28863_A2Up0.1829391974
GSE28863_A3Up0.4345168313
GSE28863_A4Up0.1268854801
GSE48662Down-0.4716621443

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Ethanolamine OleateDB06689 -
C1 Esterase Inhibitor (Recombinant)DB09228 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.